Acne vulgaris is a chronic inflammatory skin condition involving sebaceous gland overactivity, follicular hyperkeratinization, oxidative stress, inflammatory signaling, altered skin microbiome balance, and increased sebum accumulation within hair follicles. The condition commonly affects the face, chest, shoulders, neck, and back where sebaceous glands are highly concentrated. Acne lesions may include blackheads, whiteheads, inflammatory papules, pustules, nodules, and cyst-like eruptions associated with follicular obstruction and inflammatory cytokine activity. Sebaceous gland activity is strongly influenced by insulin signaling, IGF-1 activity, androgen signaling, inflammatory mediators, oxidative stress pathways, and dietary patterns linked to glycemic instability. Increased insulin and IGF-1 signaling may stimulate sebocyte proliferation, increase sebum synthesis, and amplify keratinocyte activity within follicles. Elevated inflammatory signaling involving NF-κB pathways, prostaglandin activity, cytokine release, oxidative stress, and lipid peroxidation may contribute to follicular inflammation and tissue irritation. Oxidative stress is an important component of acne biology. Reactive oxygen species may increase inflammatory burden while reducing antioxidant defense capacity within skin tissues. Lipid oxidation within sebum may further activate inflammatory cascades and disrupt epidermal barrier stability. Environmental pollutants, ultra-processed foods, refined sugars, fried foods, dairy intake, endocrine-disrupting chemicals, and chronic psychological stress may contribute to inflammatory signaling and hormonal imbalance associated with acne development. A whole food plant-based dietary pattern emphasizing fiber-rich legumes, vegetables, berries, cruciferous vegetables, herbs, seeds, green tea, and antioxidant-rich whole foods may help support insulin balance, inflammatory regulation, antioxidant defense systems, gut microbiome stability, and skin barrier resilience. Fiber-rich foods may assist with glycemic stability and support healthy estrogen and androgen metabolism through improved microbiome activity and bile acid turnover. Broccoli, kale, blueberry, strawberry, tomato, green tea, turmeric, garlic, flax seeds, and red onion contain flavonoids, carotenoids, glucosinolates, catechins, lignans, sulfur compounds, polyphenols, and antioxidant compounds associated with inflammatory regulation, oxidative defense systems, endothelial support, and normal cellular turnover. These plant compounds may help support biological systems associated with sebum regulation, epithelial integrity, detoxification pathways, and inflammatory balance linked to acne vulgaris support.