Adrenal fatigue is a functional term commonly used to describe prolonged stress-related exhaustion patterns associated with chronic activation of the hypothalamic-pituitary-adrenal (HPA) axis. Persistent psychological stress, sleep disruption, poor dietary patterns, ultra-processed food intake, excessive stimulant use, irregular meal timing, chronic inflammation, and metabolic instability may contribute to altered cortisol rhythm, catecholamine signaling, mitochondrial strain, and impaired recovery capacity. Functional symptoms frequently associated with this pattern include fatigue, reduced mental clarity, poor stress tolerance, afternoon energy crashes, disrupted sleep, irritability, low motivation, cravings for highly processed foods, and reduced exercise resilience. The adrenal glands coordinate stress adaptation through interactions involving cortisol, epinephrine, norepinephrine, aldosterone, and related signaling pathways. Chronic inflammatory signaling, oxidative stress, blood sugar instability, and circadian rhythm disruption may influence adrenal responsiveness and downstream metabolic regulation. Research also demonstrates that chronic stress exposure can influence inflammatory mediators including NF-κB signaling, oxidative balance, mitochondrial ATP production, autonomic nervous system activation, and glucose regulation. A whole-food plant-based dietary pattern emphasizing mineral-rich vegetables, legumes, fruits, intact grains, mushrooms, herbs, and seeds may help support physiologic resilience through improved antioxidant intake, stable carbohydrate availability, fiber-mediated glycemic balance, nitric oxide support, and reduction of inflammatory dietary exposures. Foods naturally rich in vitamin C, magnesium, potassium, folate, polyphenols, carotenoids, flavonoids, and sulfur-containing phytochemicals may contribute to cellular energy pathways, oxidative defense systems, and vascular function involved in stress adaptation. Leafy greens, berries, citrus fruits, legumes, oats, brown rice, cruciferous vegetables, mushrooms, green tea, flax seeds, pumpkin seeds, and colorful vegetables provide compounds associated with AMPK signaling, glutathione defense, mitochondrial efficiency, circadian rhythm regulation, and endothelial support. Polyphenol-rich foods including blueberries, strawberries, green tea, turmeric, broccoli, kale, and pomegranate contain compounds studied for their interactions with oxidative stress pathways, inflammatory signaling, cellular repair systems, and stress-related metabolic regulation. Sleep quality, hydration, balanced meal timing, physical activity, circadian alignment, and reduced exposure to processed foods and stimulants may also influence HPA-axis balance and autonomic nervous system recovery. P53 Nutrition emphasizes a nutrient-dense whole-food plant-based strategy focused on metabolic stability, antioxidant capacity, mitochondrial support, and biologic resilience without reliance on ultra-processed foods, refined oils, dairy products, or animal-derived foods.