Adrenal imbalance associated with chronic fatigue patterns involves dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, altered cortisol signaling, impaired circadian rhythm coordination, and disturbances in cellular energy production. This pattern is commonly associated with prolonged psychological stress, chronic inflammation, blood sugar instability, disrupted sleep cycles, poor dietary quality, environmental toxin exposure, and nutrient depletion. The adrenal glands participate in the regulation of cortisol, epinephrine, norepinephrine, aldosterone, and related stress-adaptation hormones that influence blood pressure, glucose metabolism, immune signaling, electrolyte balance, mitochondrial function, and inflammatory responses. Persistent activation of stress-response pathways may contribute to elevated inflammatory cytokines, oxidative stress accumulation, impaired glucose regulation, and altered autonomic nervous system balance. Many individuals experiencing adrenal imbalance patterns report fatigue, low stress tolerance, sleep disruption, afternoon energy decline, difficulty recovering from exertion, poor concentration, irritability, sugar cravings, and fluctuating energy levels throughout the day. These symptoms often overlap with metabolic stress, inflammatory signaling, circadian disruption, and reduced mitochondrial efficiency. Plant-based dietary patterns rich in colorful vegetables, legumes, fruits, herbs, mushrooms, seeds, and whole grains provide diverse phytonutrients, minerals, vitamins, fiber, and antioxidant compounds that support stress-response physiology and cellular resilience. Nutrients involved in adrenal and mitochondrial support include magnesium, potassium, vitamin C, vitamin B5, vitamin B6, folate, manganese, copper, and amino acids involved in neurotransmitter and glutathione pathways. Polyphenols and flavonoids from berries, green tea, cruciferous vegetables, leafy greens, garlic, turmeric, and mushrooms are associated with modulation of oxidative stress pathways including Nrf2 antioxidant signaling, NF-κB signaling, mitochondrial defense systems, and inflammatory mediators. Stable blood glucose regulation is also important for reducing repeated cortisol activation. Whole-food plant-based meals emphasizing fiber-rich legumes, intact whole grains, vegetables, and low-glycemic fruits may help support insulin signaling and reduce rapid glucose fluctuations that can contribute to stress hormone activation. Circadian regulation is closely linked with adrenal rhythm balance, and nutritional patterns that support regular meal timing and antioxidant defense may assist biological recovery systems. Supportive nutritional strategies focus on restoring antioxidant capacity, supporting mitochondrial metabolism, reducing inflammatory burden, improving mineral balance, and enhancing resilience of stress-response pathways. Emphasis is placed on minimally processed plant foods without refined oils, excess sodium, highly processed sugars, or inflammatory dietary patterns. A broad spectrum of phytochemicals and micronutrients may help support healthy endocrine signaling, energy metabolism, and physiological recovery processes associated with chronic fatigue-related adrenal imbalance.