Cheilitis involving cracked, dry, inflamed lips is commonly associated with dehydration, environmental irritation, nutritional imbalance, oxidative stress, impaired epithelial barrier integrity, and chronic exposure to drying conditions. The lips contain thin epithelial tissue with limited sebaceous protection, making them highly sensitive to low hydration status, nutrient insufficiency, cold air exposure, ultraviolet stress, mouth breathing, excessive processed food intake, and inflammatory metabolic conditions. Repeated irritation may weaken the epithelial barrier and increase tissue dryness, fissuring, redness, tenderness, and surface breakdown. Nutritional factors linked with lip cracking commonly include low intake of vitamin B2, vitamin B3, vitamin B6, vitamin C, iron, zinc, and amino acids involved in epithelial maintenance and collagen-related tissue support. Oxidative stress and inflammatory signaling may further impair normal tissue renewal within the lip surface. Reduced intake of antioxidant-rich whole foods may limit the availability of carotenoids, flavonoids, polyphenols, and mineral cofactors needed for normal epithelial repair pathways and hydration balance. A whole food plant-based dietary pattern emphasizing hydrating fruits, mineral-rich vegetables, legumes, seeds, leafy greens, and antioxidant-containing whole foods may help support epithelial barrier integrity, hydration balance, collagen biosynthesis, antioxidant defense systems, and oral tissue resilience. Water-rich fruits and vegetables naturally provide potassium, vitamin C compounds, carotenoids, polyphenols, and flavonoids associated with hydration support and tissue maintenance. Fiber-rich plant foods may also support gut microbiome signaling and nutrient absorption pathways involved in healthy skin and mucosal surfaces. Orange, kiwi, strawberry, cucumber, tomato, red-onion, kale, broccoli, chia-seeds-whole-dried, and green-tea-brewed contain compounds associated with antioxidant activity, epithelial support, hydration regulation, and inflammatory balance. Citrus fruits and berries provide vitamin C compounds linked to collagen biosynthesis and connective tissue integrity. Leafy greens and cruciferous vegetables contribute carotenoids, glucoraphanin, lutein, and mineral cofactors associated with cellular protection systems. Seeds and legumes provide amino acids and trace minerals important for epithelial renewal and structural tissue maintenance. Environmental dryness, excessive sodium intake, low water intake, chronic oxidative burden, inflammatory processed foods, smoking exposure, and repeated lip irritation may worsen epithelial barrier dysfunction. Supporting hydration, antioxidant intake, mineral balance, and whole-food nutrient density may help maintain healthier lip tissue integrity and normal epithelial resilience.