High triglycerides are a metabolic condition involving elevated circulating triglyceride-rich lipoproteins in the bloodstream. Triglycerides are a major form of stored energy produced from excess caloric intake, refined carbohydrate overload, excessive sugar intake, alcohol exposure, impaired insulin signaling, or excessive hepatic fat synthesis. The liver plays a central role in triglyceride metabolism through de novo lipogenesis, fatty acid packaging, very low-density lipoprotein production, glycogen regulation, mitochondrial oxidation, and glucose handling. Elevated triglycerides are commonly associated with insulin resistance, fatty liver accumulation, endothelial dysfunction, metabolic syndrome, obesity-related inflammation, oxidative stress, and impaired lipid clearance. Refined carbohydrates, excessive fructose intake, ultra-processed foods, added sugars, and chronic overnutrition may increase hepatic triglyceride synthesis through activation of insulin signaling, mTORC1 signaling, de novo lipogenesis, and inflammatory pathways. Excess caloric intake may increase fatty acid accumulation inside hepatocytes while reducing mitochondrial fatty acid oxidation efficiency. Elevated triglycerides are frequently associated with increased visceral fat accumulation, impaired glucose metabolism, chronic low-grade inflammation, endothelial irritation, oxidative stress, and altered adipokine signaling. Whole-food plant-based dietary patterns emphasizing intact fiber-rich foods may support triglyceride regulation by improving insulin sensitivity, hepatic lipid handling, gut microbiome signaling, endothelial function, mitochondrial metabolism, and satiety regulation. Soluble fiber from oats, legumes, vegetables, berries, flax seeds, chia seeds, and intact whole grains may assist bile acid handling, glucose stability, postprandial lipid balance, and gastrointestinal fermentation pathways linked to SCFA production. SCFA signaling influences hepatic metabolism, inflammation regulation, insulin sensitivity, and energy homeostasis. Polyphenol-rich fruits, vegetables, herbs, legumes, mushrooms, seeds, and teas contain phytochemicals associated with antioxidant defense, lipid metabolism support, endothelial protection, inflammatory regulation, and metabolic resilience. Anthocyanins, catechins, ellagic acid, quercetin, chlorogenic acid, lignans, carotenoids, glucosinolates, and flavonoids are associated with improved oxidative balance and metabolic pathway regulation. Green tea polyphenols, berry anthocyanins, cruciferous vegetable compounds, citrus flavonoids, and flax lignans have been studied for associations with triglyceride reduction and metabolic support. P53 Nutrition emphasizes intact whole-food plant nutrition without oils, refined sugars, dairy, or processed animal products. Fiber-rich legumes, leafy greens, berries, cruciferous vegetables, intact grains, mushrooms, seeds, herbs, and antioxidant-rich fruits provide naturally occurring nutrients and phytochemicals associated with insulin signaling balance, hepatic support, endothelial protection, mitochondrial energy production, inflammatory regulation, and healthy lipid metabolism. Hydration, physical movement, sleep quality, and minimizing processed food exposure may further support triglyceride regulation and metabolic resilience.