HPA Axis Dysregulation refers to chronic disruption of the hypothalamic-pituitary-adrenal stress response system. The HPA axis coordinates communication between the brain, adrenal glands, immune system, circadian rhythm signaling, glucose metabolism, and inflammatory regulation. Persistent psychological stress, inflammatory dietary patterns, sleep disruption, stimulant overuse, circadian imbalance, environmental toxins, and metabolic instability can contribute to prolonged activation of cortisol and catecholamine pathways. Over time, fluctuating cortisol output and altered stress signaling may influence energy production, sleep quality, mood regulation, blood sugar balance, vascular tone, digestion, immune activity, and inflammatory responses. Chronic activation of stress-response signaling increases sympathetic nervous system activity and may elevate norepinephrine and epinephrine output. Increased oxidative stress and inflammatory signaling through NF-κB, cytokine pathways, and mitochondrial dysfunction may accompany prolonged stress exposure. Disturbance of circadian rhythm regulation may impair melatonin production and disrupt cortisol timing patterns. Blood glucose instability, reactive hypoglycemia, poor meal timing, and inadequate intake of nutrient-dense whole foods may further intensify stress-related metabolic strain. Whole-food plant-based dietary patterns rich in polyphenols, minerals, fiber, amino acids, antioxidants, and phytonutrients are associated with improved endothelial function, lower inflammatory signaling, improved insulin sensitivity, and support for mitochondrial energy metabolism. Foods naturally rich in magnesium, potassium, vitamin C, folate, carotenoids, flavonoids, and polyphenols help support neurotransmitter balance, stress adaptation pathways, antioxidant defense systems, and cellular recovery mechanisms. Cruciferous vegetables such as broccoli, kale, and Brussels sprouts contain glucoraphanin and sulforaphane-associated compounds that interact with Nrf2 antioxidant pathways and cellular stress responses. Green tea provides catechins including EGCG and L-theanine, compounds studied for effects on stress signaling and autonomic balance. Berries such as blueberry and strawberry provide anthocyanins, quercetin, ellagic acid, and flavonoids associated with oxidative stress reduction and vascular support. Citrus fruits provide hesperidin, naringenin, and vitamin C which participate in adrenal hormone synthesis and antioxidant recycling systems. A structured dietary pattern emphasizing stable blood sugar regulation, hydration, adequate fiber intake, whole grains, legumes, leafy greens, seeds, berries, herbs, and polyphenol-rich foods may help support physiological resilience during chronic stress exposure. Nutritional strategies that stabilize metabolic function and reduce inflammatory burden are strongly associated with healthier neuroendocrine signaling and improved circadian rhythm regulation.