Low blood pressure, also called hypotension, is a circulatory condition involving reduced arterial pressure and decreased vascular resistance or reduced circulating blood volume. Blood pressure regulation depends on coordinated interactions between the heart, kidneys, adrenal hormones, nervous system signaling, hydration status, vascular tone, and electrolyte balance. Hypotension may contribute to dizziness, fatigue, weakness, cold extremities, exercise intolerance, lightheadedness, or reduced circulation during standing or physical stress. Hydration balance plays a central role in maintaining blood pressure stability. Reduced fluid intake, excessive sweating, inadequate sodium intake, chronic dehydration, low caloric intake, or inadequate mineral consumption may reduce plasma volume and vascular filling pressure. Potassium, magnesium, sodium, and water balance directly influence nerve conduction, muscular contraction, endothelial signaling, and kidney regulation of blood volume. The renin-angiotensin-aldosterone system and vasopressin signaling pathways help regulate vascular constriction and fluid retention during low pressure states. A whole-food plant-based dietary pattern emphasizing mineral-rich vegetables, legumes, fruits, seeds, and intact whole grains may help support vascular responsiveness and hydration physiology. Potassium-rich vegetables and fruits help maintain cellular fluid balance and support muscular and endothelial function. Magnesium-containing foods contribute to vascular tone regulation, ATP metabolism, nervous system signaling, and smooth muscle balance. Natural carbohydrate sources from intact plants may assist glycogen storage and fluid retention associated with cellular hydration. Circulatory regulation is also strongly connected to endothelial nitric oxide signaling and mitochondrial energy metabolism. Beetroot, leafy greens, watermelon, citrus fruits, legumes, and polyphenol-rich berries contain compounds associated with endothelial support, antioxidant defense, and vascular responsiveness. Polyphenols, carotenoids, flavonoids, anthocyanins, nitrate-containing vegetables, and vitamin C-rich foods help protect vascular tissue from oxidative stress and inflammatory signaling associated with impaired circulation and endothelial dysfunction. Processed foods, alcohol exposure, inadequate hydration, excessive heat exposure, severe caloric restriction, nutrient deficiencies, and chronic physiological stress may negatively affect circulatory stability and autonomic regulation. Consistent intake of water-rich fruits and vegetables together with intact plant foods may support fluid balance, mineral intake, mitochondrial energy production, and healthy vascular adaptation. P53 Nutrition emphasizes nutrient-dense plant foods containing potassium, magnesium, folate, polyphenols, flavonoids, nitrates, and antioxidant compounds that support circulatory function, hydration balance, endothelial physiology, and metabolic resilience.