Menopause is a natural endocrine transition characterized by declining ovarian hormone production, altered estrogen and progesterone signaling, changes in thermoregulation, sleep disruption, vascular instability, and metabolic adaptations associated with aging reproductive tissues. Common symptoms include hot flashes, night sweats, mood instability, fatigue, sleep disturbance, memory changes, joint discomfort, skin dryness, and shifts in body fat distribution. These biological changes are linked to fluctuating estradiol levels, altered hypothalamic signaling, inflammatory mediators, endothelial stress, oxidative burden, and changes in neurotransmitter regulation involving serotonin, dopamine, and norepinephrine pathways. Estrogen signaling plays an important role in vascular flexibility, collagen maintenance, mitochondrial activity, bone remodeling, thermoregulation, insulin signaling, and nervous system communication. As estrogen production declines, oxidative stress activity may increase while endothelial nitric oxide production, antioxidant defense systems, and collagen integrity may become less efficient. Menopause-associated symptoms are also linked to inflammatory cytokines, prostaglandin activity, altered cortisol signaling, circadian rhythm disruption, and metabolic changes involving insulin sensitivity and adipose tissue signaling. A whole food plant-based dietary pattern rich in legumes, flax seeds, sesame seeds, cruciferous vegetables, berries, leafy greens, whole grains, and polyphenol-rich plant foods may help support hormonal balance pathways, vascular stability, antioxidant defense systems, bone-supportive mineral intake, and gut microbiome diversity associated with estrogen metabolism. Fiber-rich foods may assist with estrogen metabolite regulation through gut microbiome interactions and healthy digestive elimination patterns. Plant foods naturally contain lignans, isoflavones, flavonoids, carotenoids, glucosinolates, and antioxidant compounds associated with oxidative balance and endocrine signaling support. Soybeans, edamame, flax seeds, sesame seeds, broccoli, kale, berries, green tea, chickpeas, lentils, oats, and cruciferous vegetables provide phytoestrogen compounds including genistein, daidzein, secoisolariciresinol, lignans, flavonoids, and polyphenols associated with estrogen receptor modulation and antioxidant protection pathways. Magnesium-rich leafy greens, calcium-containing plant foods, potassium-rich vegetables, and antioxidant-rich fruits may help support vascular function, hydration balance, nervous system stability, and bone remodeling systems during menopause-related endocrine transitions. Inflammatory processed foods, excessive alcohol exposure, chronic stress signaling, poor sleep quality, smoking, sedentary behavior, endocrine-disrupting chemicals, and nutrient-poor dietary patterns may increase oxidative stress burden and worsen vascular instability, sleep disruption, inflammatory signaling, and metabolic dysregulation associated with menopause symptoms.