Menstrual pain, also known as dysmenorrhea, is characterized by cramping discomfort, pelvic pressure, lower abdominal pain, fatigue, lower back discomfort, nausea, and inflammatory symptoms occurring before or during menstruation. Dysmenorrhea is strongly associated with elevated inflammatory prostaglandin production, uterine muscle contractions, oxidative stress, endothelial irritation, hormonal fluctuations, and altered pelvic blood flow. Increased prostaglandin signaling can intensify uterine contractions and vascular constriction, contributing to pain intensity and inflammatory tissue stress during the menstrual cycle. Inflammatory signaling pathways including prostaglandin synthesis, NF-κB activation, oxidative stress responses, and estrogen-related endocrine pathways may influence symptom severity. Elevated oxidative burden may increase inflammatory mediator activity while reducing mitochondrial efficiency and cellular antioxidant defenses. Stress-related cortisol signaling, inflammatory dietary patterns, inadequate mineral intake, dehydration, low fiber intake, and high processed food consumption may further aggravate inflammatory physiology associated with menstrual discomfort. A whole food plant-based dietary pattern emphasizing anti-inflammatory fruits, vegetables, legumes, herbs, seeds, and whole grains may help support inflammatory balance, endothelial circulation, antioxidant defense activity, hydration, mineral status, and hormonal metabolism pathways involved in menstrual comfort. Fiber-rich whole foods may support estrogen metabolism and gut microbiome activity associated with endocrine balance and inflammatory regulation. Plant foods naturally contain polyphenols, flavonoids, anthocyanins, carotenoids, lignans, magnesium, potassium, vitamin C compounds, and antioxidant phytochemicals associated with vascular support and inflammatory pathway modulation. Leafy greens, berries, flax seeds, ginger, turmeric, broccoli, kale, citrus fruits, green tea, pumpkin seeds, legumes, and cruciferous vegetables provide biologically active compounds linked to antioxidant defense systems and inflammatory signaling regulation. Magnesium-rich whole foods may help support muscular relaxation and endothelial function while potassium-containing foods assist hydration and electrolyte balance. Polyphenol-rich berries and green tea compounds are associated with oxidative stress regulation and circulatory support. Reducing highly processed foods, minimizing inflammatory dietary patterns, supporting hydration, and increasing intake of colorful whole plant foods may help support normal inflammatory balance and menstrual physiology. Consistent intake of fiber-rich legumes, vegetables, fruits, herbs, and seeds may assist hormone metabolism pathways, antioxidant defenses, and circulatory function associated with dysmenorrhea support.