Post-cholecystectomy adaptation refers to digestive and metabolic changes that may occur after removal of the gallbladder. The gallbladder normally stores and concentrates bile produced by the liver, releasing it in coordinated pulses during digestion. After gallbladder removal, bile continuously drips into the small intestine rather than being released in controlled amounts. This altered bile flow pattern may contribute to bloating, loose stools, digestive discomfort, altered fat tolerance, post-meal urgency, intestinal irritation, and impaired digestive rhythm in some individuals. Bile acids are important biological compounds involved in fat emulsification, cholesterol balance, microbial regulation, intestinal signaling, and nutrient absorption. Continuous bile exposure within the intestine may alter gut microbiome balance, epithelial barrier integrity, intestinal motility, and bile acid recycling systems. Excessive bile acid exposure within the colon may contribute to irritation and increased fluid secretion. Digestive adaptation may also involve altered enterohepatic circulation, hepatic signaling responses, inflammatory stress pathways, and microbiome-related metabolic changes. A whole food plant-based dietary pattern emphasizing soluble fiber, hydration, resistant starches, cruciferous vegetables, legumes, oats, brown rice, apples, leafy greens, and antioxidant-rich vegetables may help support healthy bile acid balance, gastrointestinal comfort, microbial diversity, intestinal barrier integrity, and digestive rhythm regulation. Soluble fibers naturally bind portions of bile acids within the intestine and may help moderate excessive bile acid exposure in the colon while supporting healthy elimination pathways. Foods such as oats, apples, brown rice, lentils, chickpeas, broccoli, kale, cabbage-green, banana, sweet-potato-orange, flax-seeds-whole-raw, chia-seeds-whole-dried, and artichoke contain fibers, polyphenols, glucosinolates, resistant starches, lignans, flavonoids, carotenoids, and prebiotic compounds associated with gut microbiome support and epithelial stability. Cruciferous vegetables contain glucoraphanin and sulforaphane-associated compounds linked to detoxification pathways and oxidative stress defense systems. Flax seeds and chia seeds provide soluble fibers and lignan-related compounds associated with bile acid metabolism and intestinal support. Maintaining hydration, emphasizing smaller balanced meals, increasing plant fiber gradually, and minimizing highly processed foods may help support gastrointestinal adaptation after gallbladder removal. Whole plant foods rich in phytonutrients, antioxidants, fermentable fibers, and microbiome-supportive compounds may assist biological systems involved in bile signaling regulation, intestinal resilience, and digestive recovery patterns associated with post-cholecystectomy adaptation.