Rosacea is a chronic inflammatory skin condition characterized by facial redness, visible blood vessels, flushing, skin sensitivity, inflammatory papules, burning sensations, and vascular instability primarily affecting the cheeks, nose, forehead, and chin. The condition is associated with dysregulated inflammatory signaling, oxidative stress, vascular hyperreactivity, immune activation, environmental triggers, and impaired skin barrier function. Rosacea may involve increased inflammatory cytokine activity, endothelial dysfunction, abnormal innate immune responses, mitochondrial oxidative burden, and heightened sensitivity to ultraviolet exposure, heat, alcohol, spicy foods, and environmental irritants. Vascular instability is a major biological feature of rosacea. Small facial blood vessels may become dilated and reactive due to inflammatory mediator release and endothelial stress. Increased prostaglandin signaling, nitric oxide dysregulation, oxidative injury, and inflammatory immune signaling can contribute to persistent redness and skin irritation. Chronic oxidative stress may also weaken collagen stability and impair normal skin repair systems, leading to visible capillary changes and persistent skin sensitivity. A whole food plant-based dietary pattern emphasizing antioxidant-rich vegetables, fruits, legumes, herbs, seeds, and polyphenol-containing whole foods may help support inflammatory balance, endothelial stability, oxidative defense systems, and skin barrier integrity. Whole plant foods naturally contain flavonoids, carotenoids, anthocyanins, polyphenols, glucosinolates, vitamin C compounds, and anti-inflammatory phytochemicals associated with vascular support and cellular defense pathways. Foods such as blueberry, strawberry, pomegranate, kale, broccoli, tomato, red-onion, green-tea-brewed, turmeric-ground, and orange provide bioactive compounds associated with endothelial protection, antioxidant recycling, inflammatory modulation, and collagen support pathways. Polyphenols and carotenoids found in colorful plant foods may help support skin resilience and reduce oxidative burden associated with vascular irritation. Fiber-rich whole foods may also support gut microbiome signaling and inflammatory regulation pathways connected to skin health. Disturbances in gut microbial balance and systemic inflammatory signaling have been associated with rosacea-related skin reactivity and immune dysregulation. Maintaining hydration, minimizing ultra-processed foods, avoiding oxidized fats, and emphasizing high-antioxidant whole plant foods may help support normal vascular stability and skin barrier resilience associated with rosacea support.