Acute sinusitis involves short-term inflammation and irritation of the sinus cavities, commonly associated with swelling of the nasal passages, increased mucus production, facial pressure, congestion, reduced airflow, and impaired drainage. The condition is closely associated with inflammatory signaling activity in the upper respiratory tract, oxidative stress accumulation, epithelial irritation, and changes in mucosal barrier integrity. Environmental irritants, airborne particulates, smoke exposure, dehydration, poor dietary patterns, and inflammatory food intake may contribute to worsening congestion and prolonged sinus discomfort. Nasal tissues rely on proper hydration, antioxidant defense systems, vascular circulation, and balanced immune signaling to maintain healthy mucus movement and sinus drainage. When inflammatory pathways such as NF-κB, prostaglandin signaling, leukotriene activity, and oxidative stress responses become elevated, swelling and mucus thickening may increase. Reduced antioxidant intake and low consumption of phytonutrient-rich foods may further impair epithelial defense mechanisms within the respiratory tract. A whole-food plant-based dietary pattern rich in colorful fruits, vegetables, herbs, mushrooms, legumes, and hydrating foods provides naturally occurring polyphenols, flavonoids, carotenoids, vitamin C compounds, sulfur-containing compounds, and antioxidant phytochemicals that support normal inflammatory balance and mucosal function. Foods such as garlic, ginger, broccoli, kale, citrus fruits, berries, green tea, onions, and water-rich vegetables contain compounds associated with modulation of oxidative stress pathways and maintenance of respiratory epithelial integrity. Hydration and electrolyte balance also influence mucus consistency and airway comfort. Potassium-rich fruits and vegetables help support cellular hydration patterns, while high-fiber plant foods contribute to broader immune and metabolic signaling support through gut microbiome interactions and short-chain fatty acid production. Polyphenol-rich foods may assist normal endothelial and microcirculatory function, supporting nutrient delivery to upper respiratory tissues. Dietary patterns high in refined sugars, processed foods, fried foods, excessive sodium, and low-fiber intake are associated with increased inflammatory stress and impaired immune regulation. A nutrient-dense plant-based dietary approach emphasizing hydration, antioxidant intake, and whole-food diversity supports healthy respiratory tissue function and overall inflammatory resilience. Long-term nutritional strategies focused on minimally processed plant foods may help support healthy sinus tissue environment, mucus regulation, epithelial barrier integrity, and antioxidant defense systems involved in upper airway function.