Research Documents
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Randomized Phase II Trial of Lyophilized Strawberries in Patients with Dysplastic Precancerous Lesions of the Esophagus
Abstract Dysplasia is a histologic precursor of esophageal squamous cell carcinoma (SCC). We previously showed that dietary freeze-dried, or lyophilized, strawberry powder inhibits N - nitrosomethylbenzylamine-induced SCC in the rat esophagus. On the basis of this observation, we conducted a randomized (noncomparative) phase II trial in China to investigate the effects of two doses of freeze-dried strawberries in patients with esophageal dysplastic lesions in a high-risk area for esophageal cancer. We randomly assigned 75 patients identified by endoscopy to have dysplastic esophageal premalignant lesions to receive freeze-dried strawberry powder at either 30 g/d (37 patients) or 60 g/d (38 patients) for six months; the powder was mixed with water and drunk. After six months, we assessed the changes in histologic grade of these lesions (primary endpoint) in a blinded fashion. The dose of 30 g/d, did not significantly affect histology or any other measured parameter. The dose of 60 g/d, however, reduced the histologic grade of dysplastic premalignant lesions in 29 (80.6%) of the 36 patients at this dose who were evaluated for histology (P < 0.0001). The strawberry powder was well tolerated, with no toxic effects or serious adverse events. Strawberries (60 g/d) also reduced protein expression levels of inducible nitric oxide synthase (iNOS) by 79.5% (P < 0.001), cyclooxygenase-2 (COX-2) by 62.9% (P < 0.001), phospho-nuclear factor kappa B (NF B)-p65 (pNF B-p65) by 62.6% (P < 0.001), and phospho- S6 (pS6) by 73.2% (P < 0.001). Freeze-dried strawberries (60 g/d) also significantly inhibited the Ki-67 labeling index by 37.9% (P = 0.023). Our present results indicate the potential of freeze- dried strawberry powder for preventing human esophageal cancer, supporting further clinical testing of this natural agent in this setting.
Low Protein Low Cancer Risk
Approved document in the P53 Research Library.
Stored Fat Converted to Feed Cancer Cells
Stored body fat can be broken down into fatty acids and other lipids that tumor cells can import and burn for energy, use as building blocks for membranes, and use as signaling molecules that drive proliferation.
A Genome-Wide Systems Analysis Reveals Strong Link Between Colorectal Cancer and Trimethylamine N-Oxide (TMAO), a Gut Microbial Metabolite of Dietary Meat and Fat
Genome-wide analysis identified significant associations between TMAO-related pathways and colorectal cancer.
Integrated Analysis Reveals the Gut Microbial Metabolite TMAO and POSTN as Potential Therapeutic Targets in Liver Cancer
TMAO was associated with enhanced liver cancer proliferation and invasion signaling.
Trimethylamine N-Oxide Promotes Cell Proliferation and Angiogenesis in Colorectal Cancer
TMAO increased colorectal cancer proliferation, angiogenesis, and VEGFA signaling.
Effects of low-fat or full-fat fermented and non-fermented dairy foods on selected cardiovascular biomarkers in overweight adults
Clinical trial evaluating cardiovascular biomarkers after dairy consumption.
Milk consumption for the prevention of fragility fractures
Review evaluating evidence for milk consumption and fracture prevention.
Intake of milk or fermented milk combined with fruit and vegetable consumption in relation to hip fracture rates: a cohort study of Swedish women
Examined fracture risk in relation to milk and fermented dairy intake.
Milk, fruit and vegetable, and total antioxidant intakes in relation to mortality rates: cohort studies in women and men
Higher fruit and vegetable intake appeared to modify associations observed with milk consumption.
Osteoporosis: Is milk a kindness or a curse?
Review discussing conflicting evidence regarding milk and bone health.
Nonfermented milk and other dairy products: associations with all-cause mortality
Study evaluating non-fermented milk consumption and all-cause mortality.
High vs. low-fat dairy and milk differently affects the risk of all-cause, CVD, and cancer death: A systematic review and dose-response meta-analysis of prospective cohort studies
Dose-response meta-analysis examining dairy intake and mortality outcomes.
Milk and health
Comprehensive review of milk consumption and health outcomes.
Associations of dairy intake with risk of mortality in women and men: three prospective cohort studies
Prospective cohort analysis evaluating dairy intake and mortality outcomes.
Milk intake and risk of mortality and fractures in women and men: cohort studies
Large Swedish cohort study reporting higher milk consumption was associated with increased mortality and fracture risk.
Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics
Human metabonomics study evaluating metabolic signatures associated with presence and severity of coronary heart disease.
Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function
Review of metabolomic profiling for biomarkers and mechanisms related to common cardiovascular diseases.
Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography
Classic human metabolite analysis paper relevant as background for urine and breath volatile compound measurement.
Egg n-3 fatty acid composition modulates biomarkers of choline metabolism in free-living lacto-ovo-vegetarian women of reproductive age
Human dietary study showing egg fatty acid composition can modulate biomarkers of choline metabolism.
Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
Human study using egg phosphatidylcholine challenge and clinical follow-up; TMAO was associated with major adverse cardiovascular events.
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Landmark study identifying choline, betaine, and TMAO as diet-microbe metabolites associated with cardiovascular disease risk.
The food metabolome: a window over dietary exposure
Review of food-derived metabolites and dietary exposure biomarkers relevant to diet-linked compounds including animal-food and gut microbial metabolites.
Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide
Human cardiovascular cohort study showing prognostic value of choline and betaine is linked to gut microbiota-generated TMAO.
Urinary metabolic signatures of human adiposity
Human urinary metabolomics study identifying gut microbial co-metabolites and diet-linked metabolic signatures related to adiposity and cardiometabolic risk.
The Relationship Between Trimethylamine-N-Oxide and Prevalent Cardiovascular Disease in a Multiethnic Population Living in Canada
Human multiethnic population study evaluating TMAO and prevalent cardiovascular disease.
The diet-microbe morbid union
Nature commentary on diet, gut microbes, phosphatidylcholine metabolism, TMAO, and cardiovascular disease risk.
L-carnitine consumption, its metabolism by intestinal microbiota, and cardiovascular health
Discusses L-carnitine from animal-food patterns, gut microbiota conversion to TMA/TMAO, and cardiovascular health concerns.
Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells
Mechanistic study of phytoestrogens and human metabolites on ERalpha and ERbeta activity in human cells.
Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest
Mechanistic study of estrogen receptor beta and human breast cancer cell proliferation.
Soy food consumption and breast cancer prognosis
Study evaluating soy food consumption and breast cancer prognosis.
Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the Life After Cancer Epidemiology study
Cohort study evaluating soy isoflavones and breast cancer recurrence risk.
Soy food intake and breast cancer survival
Cohort study evaluating soy food intake and breast cancer survival.
A review of the epidemiology of human breast cancer
Background epidemiology review of human breast cancer.
Migration patterns and breast cancer risk in Asian-American women
Epidemiologic study on migration patterns and breast cancer risk in Asian-American women.
Childhood soy intake and breast cancer risk in Asian American women
Study evaluating childhood soy intake and breast cancer risk in Asian American women.
Nutrition and physical activity guidelines for cancer survivors
Cancer survivor nutrition and physical activity guideline reference.
Exploring the Soyfood Controversy
Review discussing soyfood research and controversy including breast cancer context.
Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk
Study comparing soy isoflavone metabolism between rodents and humans with implications for breast cancer risk interpretation.
Post-diagnosis soy food intake and breast cancer survival: a meta-analysis of cohort studies
Meta-analysis of cohort studies evaluating soy food intake after breast cancer diagnosis and survival outcomes.
Phytoestrogens induce differential effects on both normal and malignant human breast cells in vitro
In vitro study comparing phytoestrogen effects in normal and malignant human breast cells.
Effects of Plant-Based Diets on Weight Status in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Meta-analysis of randomized controlled trials evaluated plant-based diets and weight-related outcomes in type 2 diabetes. No virus, no pill, no drug-mechanism study.
Remission of Type 2 Diabetes After Treatment With a High-Fiber, Low-Fat, Plant-Predominant Diet Intervention: A Case Series
Plant-predominant, high-fiber, low-fat dietary intervention was associated with improved HbA1c, fasting glucose, BMI, and remission in some patients. No virus, no pill, no drug-mechanism study.
Vegetarian diets and glycemic control in diabetes: a systematic review and meta-analysis
Systematic review and meta-analysis of controlled clinical trials found vegetarian diets reduced HbA1c in type 2 diabetes. No virus, no pill, no drug-mechanism study.
Effects of Vegetarian or Vegan Diets on Glycemic and Cardiometabolic Health in Type 2 Diabetes: A Systematic Review and Meta-analysis
Meta-analysis of randomized trials found vegetarian or vegan diets reduced HbA1c, LDL cholesterol, and BMI in type 2 diabetes. No virus, no pill, no drug-mechanism study.
Vegetarian and Vegan Dietary Patterns to Treat Adult Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta-analysis of randomized controlled trials found vegetarian dietary patterns likely reduce HbA1c and BMI in adults with type 2 diabetes. No virus, no pill, no drug-mechanism study.
Effect of a Brown Rice Based Vegan Diet and Conventional Diabetic Diet on Glycemic Control of Patients with Type 2 Diabetes: A 12-Week Randomized Clinical Trial
Brown-rice-based vegan diet produced greater HbA1c reduction than conventional diabetic diet in Korean adults with type 2 diabetes. No virus, no pill, no drug-mechanism study.
A low-fat vegan diet and a conventional diabetes diet in the treatment of type 2 diabetes: a randomized, controlled, 74-wk clinical trial
Seventy-four-week trial found low-fat vegan diet improved glycemia, weight, and plasma lipids compared with conventional diabetes diet recommendations. No virus, no pill, no drug-mechanism study.
A low-fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes
Low-fat vegan diet improved glycemic control and cardiovascular risk factors in adults with type 2 diabetes. No virus, no pill, no drug-mechanism study.
A whole-food, plant-based intensive lifestyle intervention improves glycaemic control and reduces medications in individuals with type 2 diabetes: a randomised controlled trial
Whole-food plant-based lifestyle intervention improved HbA1c, insulin resistance markers, weight, inflammation, and reduced glucose-lowering medication use. No virus, no pill, no drug-mechanism study.
Facts and fiction of phytotherapy for prostate cancer
Review covers phytochemicals including genistein, lycopene, curcumin, green tea, and resveratrol in prostate cancer context.
Breast Ductal Carcinoma in Situ
Background disease-context reference confirming DCIS as non-invasive breast cancer confined within ducts.
Cancers of the Appendix: Review of the Literatures
Background reference on appendix cancers and appendiceal adenocarcinoma context.
Appendiceal cancer: a review of the literature
Background reference confirming appendiceal cancer subgroups including colonic-type adenocarcinoma and mucinous neoplasm.
Skin cancer chemoprevention: strategies to save our skin
Review includes basal cell carcinoma chemoprevention strategies and EGCG as an agent under study.
Novel approaches to chemoprevention of skin cancer
Review discusses green tea polyphenols and skin cancer chemoprevention including non-melanoma skin cancer context.
Effect of liposome encapsulation of tea catechins on their accumulation in basal cell carcinomas
EGCG-containing liposomes were tested for uptake in basal cell carcinomas.
Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells
Curcumin induced p53-dependent apoptosis in human basal cell carcinoma cells.
Curcumin and Cancer
NCI evidence summary on curcumin in cancer biology; included as plant-compound context for rare thymic carcinoma.
Epigallocatechin-3-gallate and cancer: focus on the role of signaling pathways
Review notes curcumin effects in thymic carcinoma signaling and broader EGCG cancer pathways.
Current status of thymic carcinoma treatment
Background disease-context reference for thymic carcinoma biology and clinical classification.
Thymic carcinoma: a comprehensive review
Background disease-context reference for thymic carcinoma.
Curcumin inhibits proliferation and migration of thymic carcinoma cells through down-regulation of microRNA-27a
Curcumin inhibited proliferation and migration of thymic carcinoma cells.
Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation
Polyphenol mechanisms relevant to endocrine tumor signaling context; not subtype-specific to parathyroid carcinoma.
Parathyroid Carcinoma
Background disease-context reference confirming parathyroid carcinoma as a rare endocrine malignancy.
Nutritional and vitamin status in patients with neuroendocrine neoplasms
Gastroenteropancreatic neuroendocrine neoplasm patients had high risk of nutritional and vitamin deficiencies.
Assessment and State of Nutrition of Patients with Gastroenteropancreatic Neuroendocrine Tumors
Clinical nutrition status study in gastroenteropancreatic neuroendocrine tumor patients.
Nutrition and neuroendocrine tumors: An update of the literature
Review of nutrition and neuroendocrine tumors.
Neuroendocrine Tumors: A Comprehensive Review on Nutritional Approaches
Review discusses nutritional approaches in neuroendocrine tumors and plant-rich dietary patterns.
Testicular Cancer: Pathogenesis, Diagnosis and Management with Focus on Endocrine Aspects
Background disease-context reference confirming adult testicular germ cell tumor biology and classification.
Effects of curcumin on bleomycin-induced apoptosis in human malignant testicular germ cells
Curcumin was studied with bleomycin-induced apoptosis in human malignant testicular germ cells.
Effects of curcumin on bleomycin-induced oxidative stress in malignant testicular germ cell tumors
Curcumin reduced oxidative-stress markers in malignant testicular germ cell tumor models.
Curcumin inhibits AP-2γ-induced apoptosis in the human malignant testicular germ cells in vitro
Curcumin was studied in human malignant testicular germ cells.
Resveratrol analogues surprisingly effective against triple-negative breast cancer, independent of ERα
Resveratrol analogues were tested against triple-negative breast cancer cell lines.
Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappaB/AP-1-dependent and -independent pathways
Soy isoflavones suppressed breast cancer cell invasiveness through NF-kappaB/AP-1 pathways.
In vitro Biological Effects of Sulforaphane, Epigallocatechin-3-gallate, and Curcumin on Breast Cancer Cells: A Systematic Review of the Literature
Systematic review of SFN, EGCG, and curcumin effects on breast cancer cells.
Sulforaphane Suppresses the Growth of Triple-negative Breast Cancer Stem-like Cells In vitro and In vivo
Sulforaphane from broccoli suppressed growth of triple-negative breast cancer stem-like cells.
Inhibition of gastric cancer cell proliferation by resveratrol: role of nitric oxide
Resveratrol inhibited proliferation of gastric cancer cells.
Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling
Curcumin regulated proliferation, autophagy, and apoptosis in gastric cancer cells through PI3K and P53 signaling.
Curcumin and Gastric Cancer: a Review on Mechanisms of Action
Review describes curcumin mechanisms in gastric cancer including proliferation, apoptosis, invasion, and inflammation.
Dietary fiber intake and risk of gastric cancer: The Japan Public Health Center-based prospective study
Large prospective study of dietary fiber intake and gastric cancer risk.
Salivary acinic cell carcinoma: reappraisal and update
Disease-context reference for salivary acinic cell carcinoma.
Acinic cell carcinoma of the salivary glands: a literature review and update
Background reference confirming acinic cell carcinoma as a salivary gland malignancy.
A Case-Control Study of Risk Factors for Salivary Gland Cancer
Study reviewed dietary and lifestyle risk factors for salivary gland cancer.
Diet and the risk of salivary gland cancer
Vitamin C intake greater than 200 mg/day was associated with decreased salivary gland cancer risk.
Curcumin analog WZ26 induces ROS and cell death via inhibiting thioredoxin reductase 1 in cholangiocarcinoma cells
Curcumin analog WZ26 induced ROS and cell death in cholangiocarcinoma cells.
Preclinical evidence for preventive and curative effects of resveratrol on xenograft cholangiocarcinogenesis
Resveratrol showed preventive and curative effects in xenograft cholangiocarcinogenesis models.
Anti-Tumorigenic Effects of Resveratrol in Lung Cancer Cells Through Modulation of c-FLIP
Resveratrol induced apoptosis in H460 lung cancer cells through pAkt and c-FLIP modulation.
A Novel Double Carbonyl Analog of Curcumin Induces the Apoptosis of Human Lung Cancer H460 Cells
A curcumin analog induced apoptosis in human lung cancer H460 cells through ER stress activation.
Curcumin alters gene expression-associated DNA damage, cell cycle, cell survival and cell migration and invasion in NCI-H460 human lung cancer cells
Curcumin altered DNA damage, cell cycle, survival, migration and invasion pathways in NCI-H460 cells.
Combination of EGCG and curcumin suppresses the growth of non-small cell lung cancer
EGCG plus curcumin suppressed growth of A549 and NCI-H460 NSCLC cells.
Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells
Curcumin induced apoptosis in NCI-H460 cells, a large-cell lung cancer-derived NSCLC model.
The effects of thymoquinone and genistein treatment on telomerase activity, angiogenesis, and apoptosis in thyroid cancer cell lines
Genistein and thymoquinone were evaluated in thyroid cancer cell lines for telomerase, angiogenesis, and apoptosis effects.
Resveratrol Inhibits the Tumorigenesis of Follicular Thyroid Cancer via ST6GAL2-Regulated Activation of the Hippo Signaling Pathway
Resveratrol inhibited FTC tumorigenesis through ST6GAL2 and Hippo pathway activation.
Curcumin Induces Ferroptosis in Follicular Thyroid Cancer by Upregulating HO-1 Expression
Curcumin inhibited FTC growth through HO-1-associated ferroptosis signaling.
Antiproliferative and apoptosis-inducing activity of curcumin in human gallbladder adenocarcinoma cells
Curcumin inhibited proliferation and induced apoptosis in HAG-1 human gallbladder adenocarcinoma cells.
Curcumin induces apoptosis in gallbladder carcinoma cell line GBC-SD cells
Curcumin induced apoptosis in gallbladder carcinoma cells.
Nutrition and pancreatic cancer
Review reported consistent inverse relationships between pancreatic cancer and fruit/vegetable intakes, especially markers such as fiber and vitamin C.
Curcumin inhibits pancreatic cancer cell proliferation by regulating Beclin1 expression and inhibiting the hypoxia inducible factor-1α-mediated glycolytic pathway
Curcumin inhibited pancreatic cancer cell proliferation through Beclin1/HIF-1α/glycolysis-related mechanisms.
Curcumin Induces Pancreatic Adenocarcinoma Cell Death Via Reduction of the Inhibitor of Apoptosis Survivin
Curcumin induced pancreatic cancer cell death through survivin reduction.
Cruciferous vegetable consumption and pancreatic cancer
Cruciferous vegetable intake was studied in relation to pancreatic cancer risk; used as pancreas-site nutrition evidence.
Pancreatic acinar cell carcinoma: A comprehensive review
Background disease-context reference confirming pancreatic acinar cell carcinoma as a rare pancreatic malignancy.
Fruit, vegetable, and fiber intake in relation to cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition
EPIC review covering plant foods and cancer risk across multiple sites, including gastrointestinal cancers.
Diet and lifestyle in relation to small intestinal cancer risk
Review summarizes diet and lifestyle evidence for small intestinal cancer risk, including fiber and whole grains.
Prospective study of dietary fiber, whole grain foods, and small intestinal cancer
Fiber from grains and whole-grain foods were inversely associated with small intestinal cancer incidence.
The Natural Polyphenol Curcumin Induces Apoptosis by Suppressing STAT3 Signaling in Esophageal Squamous Cell Carcinoma
Curcumin suppressed STAT3 signaling and induced apoptosis in esophageal squamous cell carcinoma models.
A Long-Acting Curcumin Nanoparticle/In Situ Hydrogel Composite for the Treatment of Uveal Melanoma
Curcumin nanoparticle hydrogel showed activity in uveal melanoma treatment models.
Epigallocatechingallate inhibits migration of human uveal melanoma cells via downregulation of matrix metalloproteinase-2 activity and ERK1/2 pathway
EGCG inhibited migration of human uveal melanoma cells through MMP-2 and ERK1/2 pathway effects.
Quercetin Impairs the Growth of Uveal Melanoma Cells by Metabolic Reprogramming
Quercetin impaired uveal melanoma cell growth, glycolysis, ATP synthesis, and cell viability.
Curcumin induces cell death in human uveal melanoma cells through mitochondrial pathway activation
Curcumin showed selective cytotoxic effects on cultured human uveal melanoma cells.
Resveratrol inhibits uveal melanoma tumor growth via early mitochondrial dysfunction
Resveratrol inhibited uveal melanoma tumor growth and induced apoptosis through mitochondrial mechanisms.
Protection of Dietary Polyphenols against Oral Cancer
Dietary polyphenols were reviewed for oral cancer protection mechanisms relevant to head and neck epithelial cancers.
Curcumin treatment suppresses IKKβ kinase activity in saliva of head and neck cancer patients
Curcumin inhibited IKKβ kinase activity and inflammatory cytokine expression in HNSCC patient saliva.
New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects
Review includes curcumin and resveratrol effects in salivary gland cancer models.
Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas
Curcumin and resveratrol reduced growth of salivary gland cancer cells and HNSCC models.
Resveratrol and Curcumin in Treatment of Gliomas
Review focused on resveratrol and curcumin research in gliomas.
Modulation of glioma risk and progression by dietary nutrients and anti-inflammatory agents
Review discusses dark yellow vegetables, beans, curcumin, and other dietary factors in glioma biology.
Healthy dietary patterns, foods, and risk of glioma: a systematic review and meta-analysis
Healthy patterns rich in vegetables, fruits, nuts, legumes, and whole grains were associated with lower glioma risk.
Curcumin Inhibits Growth of Human NCI-H292 Lung Cancer Cells
Curcumin inhibited NCI-H292 lung cancer cell growth through STAT3/FOXA2 signaling.
Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1
EGCG suppressed lung cancer cell growth through G3BP1-related signaling.
Epigallocatechin Gallate and Curcumin Strongly Inhibit NSCLC Cell Growth
EGCG and curcumin inhibited non-small cell lung cancer cell growth.
Potential anti-cancer effect of curcumin in human lung squamous cell carcinoma
Curcumin was studied in human lung squamous cell carcinoma SK-MES-1 cells.
Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway
Curcumin targeted JAK/STAT3 signaling in papillary thyroid cancer and cancer stem-like cells.
Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer Cells
Quercetin decreased proliferation and increased apoptosis in human papillary thyroid cancer cells.
Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism
Resveratrol induced apoptosis in papillary and follicular thyroid cancer cell lines.
Curcumin induces endoplasmic reticulum stress-associated apoptosis in human papillary thyroid carcinoma BCPAP cells
Curcumin inhibited thyroid cancer cell growth through ER-stress-associated apoptosis.
Quercetin-Rich Extracts from Onions Play Potent Cytotoxicity on Adrenocortical Carcinoma Cell Lines, and Quercetin Induces Important Anticancer Properties
Quercetin-rich onion extracts and quercetin showed cytotoxic effects in ACC cell lines.
Meningioma: Diagnosis and Treatment
Background disease-context reference only; NCI confirms meningioma as a primary CNS tumor and describes grades.
Curcumin Inhibits HGF-Induced EMT by Regulating c-MET-Dependent PI3K/Akt/mTOR Signaling Pathways in Meningioma
Curcumin inhibited HGF-induced proliferation, migration, invasion and EMT in malignant meningioma cells.
Quercetin induces apoptosis in meningioma cells through the PI3K/Akt/mTOR signaling pathway
Quercetin reduced viability and induced apoptosis in meningioma cells.
Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas
Curcumin showed anti-proliferative and pro-apoptotic activity in meningioma cells.
Synergistic action of dietary phyto-antioxidants on survival and proliferation of ovarian cancer cells
Indole-3-carbinol and resveratrol showed synergistic effects on ovarian cancer cell survival and proliferation.
The use of natural compounds for the targeting and chemoprevention of ovarian cancer
Review covers curcumin, EGCG, resveratrol, sulforaphane and other natural compounds in ovarian cancer.
Resveratrol inhibits the progression of cervical cancer by suppressing HPV E6 and E7 expression
Resveratrol inhibited cervical cancer development by suppressing HPV E6/E7 and promoting apoptosis.
Curcumin Induces ER Stress-Mediated Apoptosis Through Selective Generation of Reactive Oxygen Species in Cervical Cancer Cells
Curcumin promoted ER-stress-mediated apoptosis in cervical cancer cells.
The Effects of Curcumin-based Compounds on Proliferation and Cell Death in Cervical Cancer Cells
Curcumin-based compounds showed cytotoxic and anti-proliferative activity in HeLa cervical cancer cells.
Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells
Curcumin counteracted estradiol-driven proliferation and induced apoptosis in cervical cancer cells.
Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NF-kB and AP-1 translocation, and modulation of apoptosis
Curcumin showed antitumor and antiviral effects in HPV-associated cervical cancer cells.
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells
Resveratrol triggered apoptosis and reduced AKT activity in human uterine cancer cell lines.
Epigallocatechin-3-gallate potentiates curcumin’s ability to suppress uterine leiomyosarcoma cell growth and induce apoptosis
EGCG enhanced curcumin effects against uterine leiomyosarcoma cell growth and apoptosis.
Curcumin targets the AKT-mTOR pathway for uterine leiomyosarcoma tumor growth inhibition
Curcumin inhibited uterine leiomyosarcoma tumor growth in vivo by targeting AKT-mTOR signaling.
Curcumin induces cross-regulation between autophagy and apoptosis in uterine leiomyosarcoma cells
Curcumin reduced uterine leiomyosarcoma proliferation and regulated apoptosis/autophagy.
Curcumin disrupts uterine leiomyosarcoma cells through AKT-mTOR pathway inhibition
Curcumin inhibited uterine leiomyosarcoma cell growth through AKT-mTOR pathway inhibition.
Diet and nasopharyngeal carcinoma: a case-control study in Guangzhou, China
Cases consumed significantly fewer fresh vegetables and fruits than controls.
Dietary fiber intake from fresh and preserved food and risk of nasopharyngeal carcinoma
Dietary fiber intake from fresh foods was evaluated in relation to nasopharyngeal carcinoma risk.
Consumption of fruit, vegetables, and other food groups and nasopharyngeal carcinoma risk
Vegetable consumption was protective against nasopharyngeal carcinoma in a low-risk population.
Diagnosis and Treatment of Pituitary Adenomas: A Review
Background reference confirming pituitary adenomas as hormone-secreting or mass-effect tumors; included for disease context only.
Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation
Review of quercetin, EGCG, curcumin and resveratrol mechanisms relevant to endocrine and tumor signaling.
Curcumin for the treatment of pituitary adenomas
Review of curcumin mechanisms in pituitary adenomas including tumor growth and hormone hypersecretion.
Effects of resveratrol on cell growth and prolactin synthesis in rat pituitary tumor cells
Resveratrol inhibited GH3 pituitary tumor cell growth, induced S-phase arrest and apoptosis, and affected prolactin synthesis.
Curcumin (diferuloylmethane) inhibits cell proliferation, induces apoptosis, and decreases hormone production and release in pituitary tumor cells
Curcumin inhibited pituitary tumor cell proliferation, induced apoptosis, and decreased hormone production/release.
Dietary intake of fruits and vegetables and overall survival in non-Hodgkin lymphoma
Pre-diagnostic fruit and vegetable intake was evaluated in relation to NHL survival.
Antioxidant Intake from Fruits, Vegetables and Other Sources and Risk of Non-Hodgkin Lymphoma
Fruit and vegetable antioxidant intake was evaluated for NHL and DLBCL risk.
Anti-cancer properties of quercetin in osteosarcoma
Review of quercetin effects on osteosarcoma proliferation, apoptosis, invasion and resistance.
Curcumin as an Anticancer Agent in Malignant Mesothelioma
Review of curcumin and derivatives in malignant mesothelioma.
The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells
Resveratrol suppressed growth of human malignant pleural mesothelioma cells.
Curcumin: a double hit on malignant mesothelioma
Curcumin induced mesothelioma cell death mechanisms.
EGCG induces human mesothelioma cell death by inducing reactive oxygen species and autophagy
EGCG induced apoptosis in human mesothelioma cell lines.
Modulation of glioma risk and progression by dietary nutrients and anti-inflammatory agents
Review discusses dietary nutrients and inverse associations between glioma incidence and dark yellow vegetables and beans.
Healthy dietary patterns, foods, and risk of glioma: a systematic review and meta-analysis
Healthy dietary patterns high in vegetables, fruits, nuts, legumes, and whole grains were associated with lower glioma risk.
The Role of Nutrition in HPV Infection and Cervical Cancer Prevention
Review of the relationship between nutrition, HPV infection, and cervical cancer prevention.
Dietary intake of selected nutrients and persistence of HPV infection
Fruit, vegetable, vitamin C, vitamin E, carotenoid, lycopene, lutein, and zeaxanthin intake were evaluated for HPV persistence.
The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development
Dietary antioxidants, carotenoids, and folate were reviewed for cervical cancer prevention biology.
Association of dietary intake and cervical cancer: a prevention strategy
Review discusses fruit and vegetable intake, antioxidants, and cervical cancer prevention.
Effect of polyphenol compounds on Helicobacter pylori eradication: a systematic review with meta-analysis
Meta-analysis of polyphenol compounds including curcumin, cranberry, garlic, liquorice, and broccoli for H. pylori.
Curcumin as a potential therapeutic candidate for Helicobacter pylori associated diseases
Review of anti-H. pylori effects of curcumin and related gastric pathogenesis.
Oral broccoli sprouts for the treatment of Helicobacter pylori infection: a preliminary report
Orally consumed broccoli sprouts were tested against H. pylori infection in human volunteers.
Efficacy of Sulforaphane in Eradicating Helicobacter pylori in Human Gastric Xenografts Implanted in Nude Mice
Sulforaphane eradicated H. pylori in 8 of 11 infected human gastric xenografts in mice.
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
Sulforaphane from broccoli sprouts inhibited H. pylori and prevented stomach tumors in experimental models.
Dietary isoflavone intake and all-cause mortality in breast cancer survivors
Dietary isoflavone intake was evaluated in relation to mortality among breast cancer survivors.
Impact of Soy Foods on the Development of Breast Cancer and the Prognosis of Breast Cancer Patients
Review of soy foods and breast cancer risk/prognosis.
Positive Effects of Soy Isoflavone Food on Survival of Breast Cancer Patients in China
Soy food intake was associated with longer survival and lower recurrence among breast cancer patients.
Dietary fibre intake and risk of breast cancer: a systematic review and meta-analysis
Dietary fiber consumption was significantly associated with reduced breast cancer risk.
Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid
Black raspberries, anthocyanins, and protocatechuic acid were studied for esophageal cancer chemoprevention.
Anthocyanins in black raspberries prevent esophageal tumors in rats
Black raspberry anthocyanins prevented esophageal tumors in an experimental model.
Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries
Dietary lyophilized black raspberries inhibited esophageal tumorigenesis.
Curcumin Induces Cell Death in Esophageal Cancer Cells Through Modulating Notch Signaling
Curcumin inhibited esophageal cancer cell growth through Notch signaling modulation.
Randomized Phase II Trial of Lyophilized Strawberries in Patients with Dysplastic Precancerous Lesions of the Esophagus
Freeze-dried strawberry powder was tested in patients with dysplastic precancerous esophageal lesions.
Selected micronutrients and oral and pharyngeal cancer
Micronutrients correlated with total vegetable and fruit intake showed protective associations against oral cancer.
Diet in the etiology of oral and pharyngeal cancer among women from the southern United States
Greater fruit and vegetable intake was associated with reduced oral and pharyngeal cancer risk.
Dietary factors and oral and pharyngeal cancer risk
Fruit and vegetable intake was inversely related to oral and pharyngeal cancer risk.
Foods, nutrients and the risk of oral and pharyngeal cancer
Vegetables and fruits showed significant inverse trends with oral and pharyngeal cancer risk.
Myricetin: A Multifunctional Flavonol in Biomedicine
Review includes myricetin activity in synovial sarcoma in vitro.
Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in adult human sarcoma cell lines
Plant-derived nutrient mixture was tested against sarcoma cell invasion markers including synovial sarcoma context.
In vitro modulation of MMP-2 and MMP-9 in adult human sarcoma cell lines by cytokines, inducers and inhibitors
EGCG blocked PMA-induced MMP-9 expression in synovial sarcoma cells.
An In Vitro Analysis of Eight Cell Lines Using Real-Time Cell Analysis with Mistletoe Extracts and Curcumin
Curcumin decreased cell index in synovial sarcoma cell lines.
Evidence for and Against Green Tea and Turmeric in the Management of Chronic Lymphocytic Leukemia
Review of green tea and turmeric evidence in CLL.
Clinical effects of oral green tea extracts in four patients with low grade B-cell malignancies
Green tea extract exposure was associated with clinical responses in low-grade B-cell malignancies including CLL context.
Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG
Curcumin inhibited prosurvival pathways in CLL B cells and showed sequence-dependent synergy with EGCG.
Turmeric and green tea: a recipe for the treatment of B-chronic lymphocytic leukemia
Curcumin and EGCG were described as affecting apoptotic machinery in B-CLL.
Polyphenols as Antitumor Agents Targeting Key Players in Leukemia and Lymphoma
Review discusses curcumin and other polyphenols as antitumor agents in leukemia models.
The Potential Role of Dietary Polyphenols in the Prevention and Treatment of Acute Leukemias
Review of dietary polyphenols and molecular pathways in acute leukemias including AML.
Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells induced by plant polyphenols
Plant polyphenols induced selective cytotoxic calcium overload in AML cells.
Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells
Curcumin promoted AML cell-cycle arrest and apoptosis.
Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid and silibinin on proliferation and apoptosis in acute myeloid leukemia cells
Plant polyphenols affected proliferation and apoptosis in AML cells.
Epigallocatechin-3-gallate inhibits migration and invasion of renal cell carcinoma cells
EGCG inhibited RCC proliferation, migration, invasion, and induced apoptosis.
Resveratrol-mediated apoptosis in renal cell carcinoma via the p53/AMPK/mTOR pathway
Resveratrol promoted renal cell carcinoma apoptosis through p53/AMPK/mTOR-related signaling.
EGCG inhibits growth and induces apoptosis in renal cell carcinoma
EGCG inhibited growth and induced apoptosis in renal cell carcinoma cells.
Curcumin Promotes Cell Cycle Arrest and Inhibits Survival of Human Renal Cancer Cells
Curcumin inhibited survival and promoted apoptosis in renal cancer cells.
Phytochemicals for the Prevention and Treatment of Renal Cell Carcinoma
Systematic review of plant-derived compounds in renal cell carcinoma.
Antitumor and apoptotic effects of quercetin on human melanoma cells
Quercetin inhibited A375SM melanoma cell growth through apoptosis.
Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells
Sulforaphane induced apoptosis in melanoma cell lines through p53 and p38-related signaling.
Antitumor activity and expression profiles of genes induced by sulforaphane in human melanoma cells
Sulforaphane decreased melanoma cell viability and promoted apoptosis.
Resveratrol is a potent inducer of apoptosis in human melanoma cells
Resveratrol induced apoptosis in human melanoma cells.
Epigallocatechin-3-gallate causes apoptosis of melanoma cells
EGCG induced cell-cycle arrest and apoptosis in melanoma cells.
Resveratrol interrupts the pro-invasive communication between cancer associated fibroblasts and cholangiocarcinoma cells
Resveratrol disrupted pro-invasive signaling between cancer-associated fibroblasts and cholangiocarcinoma cells.
Resveratrol inhibits cell growth in a human cholangiocarcinoma cell line
Resveratrol inhibited growth of a human cholangiocarcinoma cell line.
Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis
Curcumin showed anticarcinogenic potential in cholangiocarcinogenesis models.
Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways
Curcumin suppressed proliferation and induced apoptosis in human biliary cancer cells.
Study of EGCG induced apoptosis in lung cancer cells by inhibiting PI3K/Akt signaling pathway
EGCG inhibited proliferation and induced apoptosis in H1299 lung cancer cells.
Epigallocatechin gallate promotes p53 accumulation and activity via the inhibition of MDM2-mediated p53 ubiquitination in human lung cancer cells
EGCG inhibited growth of human lung cancer cells through p53-related mechanisms.
Dietary patterns and risk of pancreatic cancer in a large population-based case-control study
A prudent pattern including vegetables, fruit, and whole grains was studied for pancreatic cancer risk.
Cruciferous vegetable consumption and the risk of pancreatic cancer: a meta-analysis
High cruciferous vegetable intake was associated with decreased pancreatic cancer risk.
Cruciferous vegetable consumption and pancreatic cancer
Cruciferous vegetable intake was associated with lower odds of pancreatic cancer.
Dietary Fiber Intake and Risk of Pancreatic Cancer
Dietary fiber intake was associated with reduced pancreatic cancer risk.
SBF-1 preferentially inhibits growth of highly malignant human liposarcoma cells
SBF-1, a steroidal glycoside compound, inhibited growth of highly malignant human liposarcoma cells.
Effects of nutritional antioxidants on AAPH- or AGEs-induced oxidative stress in human liposarcoma SW872 cells
Caffeic acid and quercetin were tested in SW872 liposarcoma oxidative-stress models.
Anti-proliferative activity of epigallocatechin-3-gallate and silibinin on soft tissue sarcoma cells
EGCG and silibinin were tested against soft-tissue sarcoma cell lines.
Inhibition of sarco/endoplasmic reticulum Ca2+-ATPase 2 by curcumin induces ER stress-associated apoptosis for treating human liposarcoma
Curcumin inhibited human liposarcoma cell survival and induced ER-stress-associated apoptosis.
Growth inhibitory effect of quercetin on SW 872 human liposarcoma cells
Quercetin inhibited SW872 human liposarcoma cell growth and induced apoptosis.
The cucurbitacins E, D and I: investigation of their cytotoxicity toward chondrosarcoma cells
Cucurbitacins from plant sources showed apoptotic activity in chondrosarcoma cells.
Identification of medicinal compounds as potential therapeutics against chondrosarcoma
Artocarpetin and 5-galloylquinic acid were identified as candidate compounds against chondrosarcoma cell lines.
Antitumor effect of resveratrol on chondrosarcoma cells
Resveratrol inhibited proliferation and induced apoptosis in chondrosarcoma cells.
Andrographolide induces cell cycle arrest and apoptosis in human chondrosarcoma cells
Andrographolide, a plant-derived compound, induced cell-cycle arrest and apoptosis in chondrosarcoma cells.
Curcumin induces cell apoptosis in human chondrosarcoma cells
Curcumin induced apoptosis in human chondrosarcoma cells.
Food groups and laryngeal cancer risk: a case-control study
Increasing vegetables and fruit was associated with reduced laryngeal cancer risk.
Diet diversity and the risk of laryngeal cancer
A varied diet rich in fruits and vegetables was related to decreased laryngeal cancer risk.
Plant foods and risk of laryngeal cancer: a case-control study
Fruits and raw vegetables were associated with strong reduction in laryngeal cancer risk.
Nutrient-based dietary patterns and laryngeal cancer
Diets rich in fruits and vegetables were inversely related to laryngeal cancer risk.
A review of association of dietary factors in gallbladder cancer
Adequate intake of fruits and vegetables may reduce gallbladder cancer risk.
Intake of cruciferous vegetables modifies bladder cancer survival
Cruciferous vegetable intake was evaluated in relation to bladder cancer survival.
Consumption of raw cruciferous vegetables is inversely associated with bladder cancer risk
Raw cruciferous vegetable intake was inversely associated with bladder cancer risk.
Modulation of glioma risk and progression by dietary nutrients and anti-inflammatory agents
Review discusses dietary nutrients and inverse associations between glioma incidence and dark yellow vegetables and beans.
Healthy dietary patterns, foods, and risk of glioma: a systematic review and meta-analysis
Healthy dietary patterns high in vegetables, fruits, nuts, legumes and whole grains were associated with lower glioma risk.
EF24 and ZSTK474 emphasize the effect of PI3K inhibition in medullary thyroid carcinoma
EF24, a curcumin analog, was studied in medullary thyroid carcinoma signaling and viability.
Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer
Resveratrol induced apoptosis and suppressed neuroendocrine markers in medullary thyroid cancer cells.
Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers
Review covers phytochemicals including resveratrol, genistein and curcumin across thyroid cancer types including medullary thyroid cancer.
Plant natural products with anti-thyroid cancer activity
Review includes medullary thyroid cancer and plant compounds such as resveratrol, curcumin, isoflavones, glucosinolates and quercetin.
Pesticide residue intake from fruit and vegetable consumption and risk of glioma
Fruit and vegetable intake by pesticide-residue burden was evaluated in relation to glioma risk.
Modulation of glioma risk and progression by dietary nutrients and anti-inflammatory agents
Review discusses dietary nutrients and inverse associations between glioma incidence and dark yellow vegetables and beans.
Prospective study of intake of fruit, vegetables, and carotenoids and the risk of adult glioma
Fruit, vegetable and carotenoid intake were examined in relation to adult glioma risk.
Healthy dietary patterns, foods, and risk of glioma: a systematic review and meta-analysis
Healthy dietary patterns high in vegetables, fruits, nuts, legumes and whole grains were associated with lower glioma risk.
Dietary Factors and Risk of Glioma in Adults: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies
Tea, total vegetables, green vegetables and orange vegetables were associated with reduced glioma risk.
Case-control study of dietary patterns and endometrial cancer risk
A mostly plant-based dietary pattern was associated with reduced endometrial cancer risk.
Association between dietary fiber and endometrial cancer: a dose-response meta-analysis
Higher total dietary fiber and vegetable fiber intakes were inversely associated with endometrial cancer risk in case-control studies.
Legume, soy, tofu, and isoflavone intake and endometrial cancer risk
Greater consumption of isoflavone-containing foods was associated with reduced endometrial cancer risk.
Soya food intake and risk of endometrial cancer among Chinese women
Regular consumption of soy foods was inversely associated with endometrial cancer risk.
Phytoestrogen intake and endometrial cancer risk
Phytoestrogenic compounds from plant foods were associated with reduced endometrial cancer risk.
Dietary phytoestrogen intake is associated with reduced colorectal and prostate cancer risk
Dietary phytoestrogens from plant foods were associated with reduced prostate cancer risk.
Soy and isoflavone consumption in relation to prostate cancer risk in China
Soy food and isoflavone intake were evaluated in relation to prostate cancer risk.
Soy Consumption and the Risk of Prostate Cancer
Soy foods and isoflavones were associated with lower prostate cancer risk.
Flaxseed supplementation reduces prostate cancer proliferation rates in men presurgery
Flaxseed supplementation was associated with lower prostate tumor proliferation.
Modifiable lifestyle factors and ovarian cancer incidence in women
Review supports fruit, vegetable, bulb vegetable, and whole-grain food patterns for ovarian cancer prevention.
Dietary fat intake and risk of epithelial ovarian cancer
Vegetable fiber consumption was associated with decreased epithelial ovarian cancer risk.
Dietary fiber intake is associated with a reduced risk of ovarian cancer
Dietary fiber intake from vegetable, fruit, cereal, and legume sources was associated with reduced ovarian cancer risk.
Association between dietary intake and risk of ovarian cancer
Green leafy vegetables, allium vegetables, fiber, flavonoids, and green tea intake were associated with reduced ovarian cancer risk.
Intakes of selected nutrients and food groups and risk of ovarian cancer
Dietary fiber, carotenoids, vitamin E, beta-carotene, and total fruit and vegetable intake were associated with reduced ovarian cancer risk.
Association of whole grain, refined grain, and cereal consumption with gastric cancer risk
Whole grain consumption was associated with decreased gastric cancer risk.
Grain Consumption and Risk of Gastric Cancer
High whole-grain intake may be protective against gastric cancer.
Fruits and vegetables intake and gastric cancer risk
Low intake of fruits and vegetables is a risk factor for gastric cancer.
Dietary patterns and gastric cancer risk: a systematic review and meta-analysis
Healthy diets rich in fruits and vegetables were associated with lower gastric cancer risk.
Dietary fiber intake reduces risk for gastric cancer: a meta-analysis
Dietary fiber intake was inversely associated with gastric cancer risk.
Intake of fiber and fiber-rich plant foods is associated with a lower risk of renal cell carcinoma
Fiber and fiber-rich plant foods were associated with significantly lower renal cell carcinoma risk.
Intakes of fruit, vegetables, and carotenoids and renal cell cancer risk
Fruit and vegetable consumption was associated with reduced renal cell cancer risk.
Intakes of Fruits, Vegetables, Vitamins A, C, and E, and Carotenoids and Risk of Renal Cell Cancer
Fruit and vegetable consumption was associated with decreased renal cell cancer risk in men.
Vegetable and Fruit Consumption and Risk of Renal Cell Carcinoma
Vegetable and fruit consumption was evaluated in relation to renal cell carcinoma risk.
Fruits, vegetables and risk of renal cell carcinoma
High fruit and vegetable consumption was associated with reduced renal cell carcinoma risk.
Soluble and Insoluble Dietary Fiber Consumption and Risk of Colorectal Cancer
Both soluble and insoluble fiber consumption appeared protective against colorectal cancer.
Dietary intake of fiber and decreased risk of cancers of the colon and rectum
Fiber-rich foods were inversely related to risk of cancers of the colon and rectum.
Dietary fibre and the risk of colorectal cancer: a case-control study
Vegetable fiber and total fiber were associated with protection against colorectal cancer.
Dietary fiber intake and risk of colorectal cancer and incident and recurrent adenoma
Higher dietary fiber intake was associated with reduced distal colorectal adenoma and distal colon cancer risk.
Diet and Esophageal Cancer Risk: An Umbrella Review of Systematic Reviews and Meta-Analyses
Higher intake of whole grains, fruits, green leafy vegetables and green tea was inversely associated with esophageal cancer risk.
Food group intake and risk of subtypes of esophageal and gastric cancer
EAC subjects tended to report lower fruit, vegetable and whole grain intake.
Dietary Factors and the Risks of Esophageal Adenocarcinoma and Barrett’s Esophagus
Dietary factors including whole grains, fruits and vegetables were studied in esophageal adenocarcinoma and Barrett’s esophagus.
Low Fruit and Vegetable Consumption in Areas of High Cholangiocarcinoma Risk in Northeastern Thailand
Study documented low fruit and vegetable consumption in regions with high cholangiocarcinoma risk.
The role of diet and nutrition related indicators in biliary diseases
Review reported inverse associations between fruit and vegetable consumption and bile duct cancer incidence.
Diet and biliary tract cancer risk in Shanghai, China
Foods with more anti-inflammatory properties were associated with lower biliary tract cancer risk.
The relationship between vegetable/fruit consumption and gallbladder/bile duct cancer: a population-based cohort study in Japan
Increased vegetable and fruit consumption was associated with lower extrahepatic bile duct cancer risk.
Exploring the Mechanism of Curcumin on Retinoblastoma Based on Network Pharmacology and Molecular Docking
Study explored curcumin mechanisms against retinoblastoma using network pharmacology and molecular docking.
The Synergistic Cytotoxic and Apoptotic Effect of Resveratrol and Naringenin on Human Retinoblastoma Y79 Cells
Resveratrol and naringenin decreased viability and increased apoptosis in retinoblastoma cells.
Expression profile of genes regulated by curcumin in Y79 retinoblastoma cells
Curcumin regulated genes involved in apoptosis, tumor suppression and cell-cycle arrest in Y79 cells.
Curcumin exerts antitumor effects in retinoblastoma cells by activating the JNK and p38 MAPK pathways
Curcumin induced apoptosis in Y79 retinoblastoma cells through JNK and p38 MAPK signaling.
Mitochondria as the primary target of resveratrol-induced apoptosis in human retinoblastoma cells
Resveratrol induced apoptosis in human retinoblastoma tumor cells through mitochondrial mechanisms.
The Association between Tea Consumption and Nasopharyngeal Cancer
Habitual tea consumption was evaluated in relation to NPC prevention.
Dietary patterns and risk of nasopharyngeal carcinoma
Fresh vegetables and fruits were included among dietary factors linked to NPC risk.
Diet Quality Scores and Risk of Nasopharyngeal Carcinoma in Chinese Adults
Higher diet quality patterns emphasizing plant foods were studied in NPC risk.
Lowered Risk of Nasopharyngeal Carcinoma and Intake of Plant Foods
Vegetables, fruits, and soybean milk were evaluated in relation to NPC risk.
Greater intake of fruit and vegetables is associated with a lower risk of nasopharyngeal carcinoma in Chinese adults
Greater fruit and vegetable intake was associated with lower NPC risk.
Protection of Dietary Polyphenols against Oral Cancer
Dietary polyphenols from plant foods were reviewed for oral cancer protection mechanisms.
Diet and oral, pharyngeal, and esophageal cancer
Review found evidence supporting a preventive role of vegetables including green, cruciferous and yellow vegetables.
Food groups and risk of oral and pharyngeal cancer
Additional servings of fruit or vegetables were associated with substantially lower oral and pharyngeal cancer risk.
Chemopreventive role of fruits and vegetables in oropharyngeal cancers
Review focused on fruit and vegetable intake in chemoprevention of oropharyngeal cancers.
Cruciferous vegetables intake reduces pancreatic cancer risk
Cruciferous vegetables were reviewed in relation to pancreatic cancer risk; broader pancreas nutrition evidence for PNET context.
Fruit and vegetable consumption in relation to pancreatic cancer risk
Fruit and vegetable intake studied in relation to pancreatic cancer risk; used as pancreas-context nutrition evidence.
Fruit and vegetable consumption is inversely associated with having pancreatic cancer
Broader pancreatic cancer evidence showing lower consumption of fruits, vegetables, whole grains and fiber associated with pancreatic cancer.
Neuroendocrine Tumors: A Comprehensive Review on Nutritional Approaches
Review discusses antioxidant and anti-inflammatory dietary patterns including whole grains, vegetables and fruits in neuroendocrine tumor care.
Impact of Nutritional Status on Gastroenteropancreatic Neuroendocrine Tumors
GEP-NET patients consumed vegetables, fruits and nuts less frequently and had lower Mediterranean diet adherence with more aggressive disease.
Inhibitory effect of curcumin on invasion of skin squamous cell carcinoma A431 cells
Curcumin reduced invasive ability of A431 skin SCC cells through STAT3 signaling.
Curcumin inhibits skin squamous cell carcinoma tumor growth
Curcumin inhibited skin SCC growth and tumor progression mechanisms.
Polyphenols: skin photoprotection and inhibition of photocarcinogenesis
Plant polyphenols including green tea, pomegranate, grape seed, resveratrol, genistein and delphinidin support skin photoprotection mechanisms.
Food intake and risk of squamous cell carcinoma of the skin
Green leafy vegetable consumption may help prevent subsequent skin SCC.
Dietary pattern in association with squamous cell carcinoma of the skin
Dietary pattern high in meat and fat increased SCC risk; supports P53 preference for plant-focused patterns.
Resveratrol: potential as anticancer agent
Review of resveratrol mechanisms including apoptosis, antiproliferation and anti-inflammatory effects relevant to cancer biology.
Role of resveratrol in prevention and therapy of cancer
Resveratrol suppresses proliferation and inflammatory signaling across cancer models; included as pathway support for rare endocrine cancer biology.
Curcumin induces apoptosis and inhibits the growth of adrenocortical carcinoma
Curcumin induced apoptosis and inhibited adrenocortical carcinoma cell growth.
Adrenocortical Carcinoma Cells Rewire Their Metabolism After Curcumin Treatment
Curcumin reduced growth and migration of adrenocortical carcinoma cells.
Plant Natural Compounds in the Treatment of Adrenocortical Tumors
Review of plant-derived compounds including curcumin, resveratrol, quercetin and genistein in adrenocortical tumors.
Dietary Patterns and Risk of Lung Cancer: A Systematic Review and Meta-analysis
Prudent dietary patterns high in vegetables and fruit tended to be associated with lower lung cancer risk.
Pre-diagnosis dietary pattern and survival in patients with multiple myeloma
Prudent dietary pattern featured high intake of vegetables and fruits and was studied in multiple myeloma survival.
Dietary Pattern and Risk of Multiple Myeloma in Two Large Prospective Cohorts
Study evaluated dietary patterns and multiple myeloma risk in large cohorts.
Dietary intake is associated with risk of multiple myeloma and its precursor disease
Fruit intake during adolescence was associated with lower MGUS risk, a precursor condition to multiple myeloma.
Dietary and microbiome evidence in multiple myeloma and other plasma cell disorders
Review summarizes dietary and microbiome factors in multiple myeloma and plasma cell disorders.
Pre-Diagnosis Dietary Patterns and Risk of Multiple Myeloma
Healthful plant-based diet was associated with reduced multiple myeloma risk.
Dietary flavonoid intake and non-Hodgkin lymphoma risk
Higher dietary flavonoid intake from plant foods may be associated with lower NHL risk.
Intakes of fruits, vegetables, and related nutrients and the risk of non-Hodgkin lymphoma among women
Higher vegetable and cruciferous vegetable intake may reduce NHL risk among women.
Vegetables, fruit, and antioxidant-related nutrients and risk of non-Hodgkin lymphoma
Higher vegetable, green leafy vegetable, cruciferous vegetable, lutein, and zeaxanthin intake was associated with lower NHL risk.
Vegetable and fruit intake and non-Hodgkin lymphoma survival
Increasing vegetable and citrus fruit intake was associated with improved survival in NHL patients.
Dietary intake of fruit and vegetables and risk of non-Hodgkin lymphoma
Higher green leafy and cruciferous vegetable intake was associated with lower NHL risk.
Potential therapeutic strategies for human osteosarcoma
Review covering natural compounds and molecular mechanisms relevant to osteosarcoma.
Plant flavonoid taxifolin inhibits the growth, migration and invasion of human osteosarcoma cells
Taxifolin inhibited growth, migration, and invasion in osteosarcoma cells.
Curcumin promotes osteosarcoma cell death by activating miR-125a/ERRα signal pathway
Curcumin promoted apoptotic cell death in osteosarcoma cells.
Inhibition of proliferation and induction of apoptosis by EGCG in human osteogenic sarcoma cells
EGCG induced apoptosis in human osteogenic sarcoma cells.
Green tea polyphenol EGCG suppresses osteosarcoma cell growth
EGCG from green tea showed anti-osteosarcoma activity in human osteosarcoma cells.
Association between dietary folate intake and HPV infection
Dietary folate intake was negatively associated with HPV infection risk, relevant to cervical cancer prevention pathways.
Association of dietary intake and cervical cancer: a prevention strategy
Review discusses diet quality, fruit and vegetable intake, antioxidants, and cervical cancer prevention.
Diet and the risk of in situ cervical cancer among white women in the United States
Weak inverse associations were noted for carotenoids, vitamin C, folate, fruit, and vegetables/fruits.
Dietary intakes of selected nutrients and food groups and risk of cervical cancer
Findings suggested plant-based nutrients may be important in reducing cervical cancer risk.
Fruits and vegetables and cervical cancer: a systematic review and meta-analysis
Systematic review of fruits, vegetables, and cervical cancer; evidence was limited after HPV adjustment.
Fruit and vegetable consumption in relation to hepatocellular carcinoma in a multi-centre, European cohort study
Vegetable intake, but not fruit intake, was associated with lower HCC risk.
Fruit and vegetable intake and liver cancer risk: a meta-analysis
Higher vegetable intake showed beneficial association with liver cancer prevention.
Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality
Higher whole grain and dietary fiber intake were associated with lower liver cancer risk and liver disease mortality.
Association of intake of whole grains and dietary fiber with risk of hepatocellular carcinoma in US adults
Whole grain intake and possibly cereal fiber and bran were associated with reduced HCC risk.
Increased intake of vegetables, but not fruit, reduces risk for hepatocellular carcinoma: a meta-analysis
Vegetable intake was associated with lower HCC risk; each 100 g/day increase lowered risk in dose-response analysis.
Fruit and vegetables, and human cancer
High intakes of fruits and vegetables were associated with reduced cancer risk, especially digestive and respiratory tract epithelial cancers.
Association between fruit and vegetable consumption and oral cancer: a meta-analysis
Fruit and vegetable intake showed strong inverse association with oral cancer; relevant to upper aerodigestive tract SCC nutrition evidence.
Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract: the prospective EPIC-study
Higher fruit and vegetable intake was associated with reduced risk of upper aero-digestive tract cancers.
Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study
Fruit and vegetable intake was inversely associated with head and neck cancer risk, including laryngeal cancer grouping.
Nutrition and laryngeal cancer
Low intake of vitamin C, beta-carotene, and vitamin E was consistently associated with higher laryngeal cancer risk.
Vegetable, Fruit Consumption and Risk of Biliary Cancer: A Systematic Review and Meta-Analysis
Vegetable and fruit consumption may significantly reduce biliary cancer risk.
Healthy dietary patterns and incidence of biliary tract cancer
Healthy diet adherence was associated with reduced risk of extrahepatic biliary tract cancer including gallbladder cancer.
Consumption of foods and micronutrients and the risk of gallbladder cancer
Vegetable intake was inversely related to gallbladder cancer risk.
Correlates between vegetable consumption and gallbladder cancer
Study assessed vegetable intake and gallbladder cancer risk.
Diet and gallbladder cancer: a case-control study
Vegetables and fruits showed a protective association in gallbladder carcinogenesis.
Effects of green tea, black tea, and coffee consumption on the risk of esophageal cancer
Tea consumption and esophageal cancer risk were evaluated in observational studies.
Green Tea Consumption and Esophageal Cancer Risk
Green tea consumption was analyzed in relation to esophageal cancer risk.
Fruit and vegetable intake and esophageal cancer in a large prospective cohort study
Fruit and vegetable intake was inversely associated with esophageal squamous cell carcinoma risk.
Intake of whole grains and incidence of oesophageal cancer
Whole-grain intake was inversely associated with esophageal cancer risk.
Intake of fruit and vegetables and risk of esophageal squamous cell carcinoma
Fruit and vegetable intake was associated with reduced risk of esophageal squamous cell carcinoma.
Associations of dietary isothiocyanate exposure from cruciferous vegetable consumption with recurrence and progression of non-muscle-invasive bladder cancer
Dietary isothiocyanate exposure from cruciferous vegetables was studied for bladder cancer recurrence and progression.
Fruits, vegetables, and bladder cancer risk: a systematic review and meta-analysis
Fruit and vegetable intake was analyzed in relation to bladder cancer risk.
Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival
Cruciferous vegetable intake was studied in relation to bladder cancer survival.
Cruciferous vegetables, isothiocyanates, and prevention of bladder cancer
Review focused on urinary delivery of isothiocyanates and bladder cancer prevention biology.
Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention
Cruciferous vegetable and broccoli-derived isothiocyanate research related to bladder cancer prevention.
Plant-based diets to reduce prostate cancer risk and improve survivorship
Review discussing plant-based diets for prostate cancer risk and survivorship.
Adoption of a plant-based diet by patients with recurrent prostate cancer
Plant-based diet adoption was feasible among patients with recurrent prostate cancer.
Legume and isoflavone intake and prostate cancer risk
Legume and isoflavone intake were evaluated in relation to prostate cancer risk.
Association of plant-based diet index with prostate cancer risk
Healthful plant-based diet pattern was associated with lower risk of aggressive prostate cancer.
Plant-Based Diets and Disease Progression in Men With Prostate Cancer
Higher plant-food intake after diagnosis was associated with lower risk of prostate cancer progression.
Intakes of fruits, vegetables, and related vitamins and lung cancer risk
Carotenoid-rich vegetable consumption was inversely associated with lung cancer risk.
Cruciferous vegetables consumption and the risk of female lung cancer
Cruciferous vegetable intake may reduce lung cancer risk in women, especially never smokers.
Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers
Diet rich in cruciferous vegetables may reduce lung cancer risk among smokers.
Fruit and vegetable consumption and risk of lung cancer
Prospective cohort meta-analysis on fruit and vegetable intake and lung cancer risk.
Fruits, vegetables and lung cancer risk: a systematic review and meta-analysis
Fruit and vegetable intake was evaluated in relation to lung cancer risk.
Dietary fibre protective against colorectal cancer patients in Asia
Dietary fiber showed protective association in colorectal cancer studies.
Dietary legume consumption reduces risk of colorectal cancer
Higher legume intake was associated with reduced colorectal cancer risk.
Whole grain and dietary fiber intake and risk of colorectal cancer in the NIH-AARP Diet and Health Study
Whole grains and fiber-containing foods were examined in relation to colorectal cancer risk.
Dietary intake of fiber, whole grains and risk of colorectal cancer
Higher cereal fiber and whole grain intake were associated with lower colorectal cancer risk.
Dietary fibre, whole grains, and risk of colorectal cancer
Higher dietary fiber, cereal fiber, and whole grains were associated with reduced colorectal cancer risk.
Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer
Dietary flaxseed altered breast tumor biological markers.
Soy Isoflavones and Breast Cancer Risk: A Meta-analysis
Soy isoflavone consumption was associated with reduced breast cancer risk.
Dietary fibre intake and risk of breast cancer: a systematic review and meta-analysis
Dietary fiber consumption was significantly associated with reduced breast cancer risk.
Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies
Dietary fiber intake was inversely associated with breast cancer risk.
Dietary Fiber Intake in Young Adults and Breast Cancer Risk
Higher fiber intake during adolescence and early adulthood was associated with lower breast cancer risk.
