Strawberry

Strawberry

FamilyRosaceae
Importance
Strawberry is the red accessory fruit of Fragaria × ananassa, valued for its bright flavor, high vitamin C, fiber, folate, manganese, potassium, ellagitannins, anthocyanins, and fragrant berry polyphenols. Per 100 g, raw strawberry provides about 32 calories, 7.7 g carbohydrate, 2.0 g fiber, 0.67 g protein, and very little fat. Its natural sugars occur within a water-rich fruit matrix that includes soluble fiber, insoluble fiber, organic acids, minerals, aromatic compounds, and phytochemicals. The red color comes mainly from anthocyanins, especially pelargonidin derivatives, while the fresh tartness comes from citric and malic acids.

Strawberry supports everyday nourishment through vitamin C, folate, manganese, potassium, fiber, and antioxidant-active pigments. Vitamin C contributes to collagen formation, antioxidant recycling, immune barrier function, and connective tissue maintenance. Folate participates in one-carbon metabolism and DNA synthesis. Manganese supports enzyme systems involved in connective tissue formation, carbohydrate metabolism, and antioxidant defense. Fiber supports digestive movement, stool bulk, and microbial fermentation. Potassium supports fluid balance, nerve signaling, and muscle contraction.

For cancer and ailment-support nutrition, strawberry is relevant because Fragaria fruits contain anthocyanins, ellagitannins, ellagic acid, pelargonidin glycosides, cyanidin glycosides, quercetin derivatives, kaempferol derivatives, catechins, proanthocyanidins, vitamin C, pectin, and phenolic acids. These compounds connect to Nrf2-related antioxidant response, NF-kB inflammatory signaling balance, AMPK-linked metabolic regulation, insulin-related carbohydrate handling, endothelial function, phase II detoxification enzyme signaling, apoptosis-related cell signaling, cell-cycle regulation, and gut microbial conversion of ellagitannins into urolithins.

Multiple published studies have shown that freeze-dried strawberries were associated with reversal or regression of precancerous esophageal lesions, also called esophageal dysplasia. In a Phase II human trial, 60 g daily of freeze-dried strawberries for six months reduced the histologic grade of dysplastic esophageal lesions in over 80% of participants, demonstrating measurable reversal of precancerous cellular changes linked to esophageal cancer development. Researchers also documented reductions in NF-kB signaling, COX-2, iNOS, Ki-67, and other cancer-related inflammatory and proliferation pathways. The whole fruit contributes vitamin C, digestive fiber, red pigments, folate, minerals, and polyphenols tied to cellular repair, inflammatory signaling balance, vascular support, digestive function, and normal metabolic regulation.

Strawberry pairs well with citrus, apples, pears, bananas, oats, cacao, mint, ginger, walnuts, almonds, leafy greens, chia, flax, and whole grains. Its strongest nutritional identity is the combination of vitamin C-rich red fruit, low calorie density, fiber, folate, manganese, anthocyanins, ellagic acid, ellagitannins, and Fragaria-family phytochemicals connected to antioxidant, digestive, vascular, inflammatory, metabolic, and cellular defense pathways.
Region FoundStrawberry Fragaria × ananassa is cultivated throughout temperate and subtropical fruit-growing regions worldwide. Major production areas include the United States, Mexico, Spain, Turkey, Egypt, Poland, Germany, Japan, South Korea, China, Morocco, and Chile. Strawberries grow best in well-drained soils, cool to mild conditions, full sun, and managed irrigation.
Glycemic Index40.0
Glycemic Load2.28
Helps Fight These Cancers: Esophageal, Colon, Oral, Breast
Helps Fight These Ailments: Hyperlipidemia, Hypertension, Insulin Resistance
Linked Hormones:

All values per 100g
Nutrition Facts
Calories (kcal)31.9
Protein (g)0.66
Carbohydrates (g)7.65
Fiber (g)1.99
Sugars (g)4.88
Total Fat (g)0.3
Saturated Fat (g)0
Vitamins
Vitamin A (µg RAE)1
Vitamin C (mg)58.9
Vitamin D (µg)0
Vitamin E (mg)0.29
Vitamin K (µg)2.23
Vitamin B1 / Thiamin (mg)0.024
Vitamin B2 / Riboflavin (mg)0.024
Vitamin B3 / Niacin (mg)0.386
Vitamin B5 / Pantothenic Acid (mg)0.127
Vitamin B6 (mg)0.048
Vitamin B7 / Biotin (µg)0
Folate B9 (µg)24
Vitamin B12 (µg)0
Vitamin Detail Pages
Minerals
Calcium (mg)16
Iron (mg)0.41
Magnesium (mg)13
Phosphorus (mg)24
Potassium (mg)153
Sodium (mg)1
Zinc (mg)0.14
Copper (mg)0.05
Manganese (mg)0.386
Selenium (µg)0.4
Iodine (µg)0.3
Mineral Detail Pages
Amino Acids
Alanine (mg)33 mg
Arginine (mg)28 mg
Asparagine (mg)0 mg
Aspartic Acid (mg)149 mg
Cysteine (mg)6 mg
Glutamic Acid (mg)98 mg
Glutamine (mg)0 mg
Glycine (mg)26 mg
Histidine (mg)12 mg
Isoleucine (mg)16 mg
Leucine (mg)34 mg
Lysine (mg)26 mg
Methionine (mg)2 mg
Phenylalanine (mg)19 mg
Proline (mg)20 mg
Serine (mg)25 mg
Threonine (mg)20 mg
Tryptophan (mg)8 mg
Tyrosine (mg)22 mg
Valine (mg)19 mg
Amino Acid Detail Pages
Phytochemicals
Anthocyanins, pelargonidin glycosides, cyanidin glycosides, ellagitannins, ellagic acid, quercetin derivatives, kaempferol derivatives, catechins, proanthocyanidins, flavonols, phenolic acids, p-coumaric acid derivatives, ferulic acid derivatives, pectin, soluble fiber, insoluble fiber, citric acid, malic acid, vitamin C, folate, manganese, potassium, and Fragaria-family polyphenols. Research references: Giampieri F, Tulipani S, Alvarez-Suarez JM, Quiles JL, Mezzetti B, Battino M. The strawberry: composition, nutritional quality, and impact on human health. Nutrition. 2012. Basu A, Nguyen A, Betts NM, Lyons TJ. Strawberry as a functional food: an evidence-based review. Critical Reviews in Food Science and Nutrition. 2014. Aaby K, Skrede G, Wrolstad RE. Phenolic composition and antioxidant activities in flesh and achenes of strawberries. Journal of Agricultural and Food Chemistry. 2005.
Research & Notes
Research Notes:
USDA FDC via MyFoodData; page shows 166 g—values scaled to 100 g; amino acids converted mg→g and cystine→cysteine.
Clinical Trial Cancer Prev Res (Phila)
. 2012 Jan;5(1):41-50. doi: 10.1158/1940-6207.CAPR-11-0469. Epub 2011 Dec 1.



Randomized Phase II Trial of Lyophilized Strawberries in Patients with Dysplastic Precancerous Lesions of the Esophagus

Lead author: Tong Chen
Published in: Cancer Prevention Research (2012)

HHS Public Access
Author manuscript
Cancer Prev Res (Phila) . Author manuscript; available in PMC 2016 October 26.
Published in final edited form as:
Cancer Prev Res (Phila) . 2012 January ; 5(1): 41–50. doi:10.1158/1940-6207.CAPR-11-0469.
Notes:
Strawberries have been shown to reverse esophageal cancer in studies.
Randomized Phase II Trial of Lyophilized Strawberries in
Patients with Dysplastic Precancerous Lesions of the
Esophagus
Tong Chen1
, Fei Yan1
, Jiaming Qian2
, Mingzhou Guo3
, Hongbing Zhang4
, Xiaofei Tang5
,
Fang Chen6
, Gary D. Stoner7, and Xiaomin Wang8
1Division of Medical Oncology, Department of Internal Medicine, The Ohio State University,
Columbus, Ohio
2Peking Union Medical College Hospital
3Department of Gastroenterology and Hepatology, Chinese PLA General Hospital
4Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College
5Beijing Stomatological Hospital, Capital Medical University
6College of Food Science and Nutritional Engineering, China Agricultural University
7Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin,
Milwaukee, Wisconsin
8Department of Oncology, Traditional Chinese Medicine Hospital, Beijing, China


Abstract
Dysplasia is a histologic precursor of esophageal squamous cell carcinoma (SCC). We previously
showed that dietary freeze-dried, or lyophilized, strawberry powder inhibits N -
nitrosomethylbenzylamine-induced SCC in the rat esophagus. On the basis of this observation, we
conducted a randomized (noncomparative) phase II trial in China to investigate the effects of two
doses of freeze-dried strawberries in patients with esophageal dysplastic lesions in a high-risk area
for esophageal cancer. We randomly assigned 75 patients identified by endoscopy to have
dysplastic esophageal premalignant lesions to receive freeze-dried strawberry powder at either 30
g/d (37 patients) or 60 g/d (38 patients) for six months; the powder was mixed with water and
drunk. After six months, we assessed the changes in histologic grade of these lesions (primary
endpoint) in a blinded fashion. The dose of 30 g/d, did not significantly affect histology or any
other measured parameter. The dose of 60 g/d, however, reduced the histologic grade of dysplastic
premalignant lesions in 29 (80.6%) of the 36 patients at this dose who were evaluated for histology
(P < 0.0001). The strawberry powder was well tolerated, with no toxic effects or serious adverse
events. Strawberries (60 g/d) also reduced protein expression levels of inducible nitric oxide
Corresponding Author: Tong Chen, Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, 410
West 12th Ave., Room 302C, Columbus, Ohio 43210. Phone: 614-247-6842; Fax: 614-688-3550; tong.chen@osumc.edu.
Disclosure of Potential Conflicts of Interest
Dr. Gary Stoner is part owner of BerriProducts,

What they found

Researchers gave patients with esophageal dysplasia (precancerous esophageal lesions) either:

* 30 g/day freeze-dried strawberry powder
* 60 g/day freeze-dried strawberry powder

for 6 months.

The important finding:

* 30 g/day did NOT significantly improve lesions
* 60 g/day significantly reduced the histologic grade of the precancerous lesions
* 29 of 36 patients (80.6%) improved
* The improvement was statistically very strong (P < 0.0001)

This is why many nutrition researchers refer to the study as showing a partial reversal of esophageal precancerous lesions, not merely slowing progression. The pathology grade itself improved in most patients.

Pathways that were suppressed

The 60 g dose significantly reduced:
athway / Marker Reduction
iNOS (Inducible Nitric Oxide Synthase) 79.5%
COX-2 62.9%
NF-κB p65 activation 62.6%
pS6 / mTOR signaling 73.2%
Ki-67 proliferation marker 37.9%

These pathways are strongly associated with:

* Chronic inflammation
* Tumor promotion
* Cell proliferation
* Survival signaling
* Angiogenesis
* Cancer progression

Key pathway effects

NF-κB pathway

NF\kappa B \—> Inflammation \—-> Tumor\ Promotion

Strawberries suppressed activated NF-κB signaling, reducing inflammatory gene expression.

COX-2 pathway

COX-2 \—> Prostaglandins \—> Inflammation \—-> Cancer\ Progression

COX-2 is commonly elevated in esophageal cancer and dysplasia. Strawberry treatment lowered COX-2 expression substantially.

mTOR / pS6 pathway

mTOR \—-> pS6 \—-> Cell\ Growth\ and\ Proliferation

The study found strong suppression of pS6 signaling, suggesting reduced cellular growth stimulation.

iNOS pathway

iNOS \——> Nitric\ Oxide \—> Oxidative\ Stress \ —-> DNA\ Damage

iNOS is frequently elevated in inflammatory and precancerous tissues. Strawberries reduced iNOS by nearly 80%.

Equivalent fresh strawberries

The researchers used freeze-dried strawberries, which concentrate the berry compounds roughly 10-fold.

60 g freeze-dried strawberry powder is approximately equal to:

* ~1 to 1.5 pounds (450–700 g) fresh strawberries daily

depending on moisture content and processing.

Why this study became famous

It is one of the human dietary intervention trials where a whole food produced measurable improvement in biopsy-confirmed precancerous lesions and simultaneously reduced major cancer-related inflammatory pathways.
Created: 2025-10-21 09:39:47
Last Updated: 2026-06-04 08:05:23